STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
AEE95920.1Histidine triad (HIT) protein; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310: IPR019808; KEGG: tpd:Teth39_1375 histidine triad (HIT) protein; PFAM: histidine triad (HIT) protein; SPTR: Histidine triad (HIT) protein; PFAM: HIT domain. (114 aa)    
Predicted Functional Partners:
AEE95919.1
RNA modification enzyme, MiaB family; COGs: COG0621 2-methylthioadenine synthetase; InterPro IPR002792: IPR013848: IPR006638: IPR005839: IPR 006467: IPR007197: IPR020612; KEGG: cth:Cthe_0150 RNA modification protein; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: RNA modification enzyme, MiaB family; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; RNA modification enzyme, MiaB [...]
 
   0.901
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
   
   0.833
prmA
Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.
       0.793
AEE96886.1
COGs: COG0174 Glutamine synthetase; InterPro IPR008147: IPR008146: IPR004809; KEGG: ate:Athe_0643 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
  
   0.705
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
   
 
 0.510
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
     
 0.466
AEE95921.1
Two component transcriptional regulator, AraC family; COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR018060: IPR001789: IPR020449: IPR000005: IPR 018062: IPR016160; KEGG: cce:Ccel_2113 two component transcriptional regulator, AraC family; PFAM: response regulator receiver; helix-turn-helix- domain containing protein AraC type; SMART: Helix-turn-helix, AraC domain; response regulator receiver; SPTR: Putative uncharacterized protein; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix protein [...]
       0.464
AEE97529.1
COGs: COG0572 Uridine kinase; KEGG: tte:TTE1778 uridine kinase; SPTR: Phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase / Uridine kinase family.
   
 0.457
AEE95426.1
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR014001: IPR001650: IPR014021: IPR006935; KEGG: ctc:CTC00657 DNA/RNA helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: DNA/RNA helicase; PFAM: NgoFVII restriction endonuclease; Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit.
  
 
  0.408
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterPro IPR002547: IPR005121: IPR004532: IPR005146: IPR 005147; KEGG: cth:Cthe_0215 phenylalanyl-tRNA synthetase subunit beta; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; PRIAM: Phenylalanine--tRNA ligase; SPTR: Phenylalanyl-tRNA synthetase beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA sy [...]
  
    0.402
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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