Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEE95949.1PP-loop domain protein; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR005232: IPR011063; KEGG: ckr:CKR_2212 hypothetical protein; PFAM: PP-loop domain protein; SPTR: Putative uncharacterized protein; PFAM: NAD synthase; TIGRFAM: conserved hypothetical protein TIGR00268. (289 aa)    
Predicted Functional Partners:
AEE95948.1
1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: cce:Ccel_2205 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PFAM: AIR carboxylase.
 
 0.998
larC
Protein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family.
  
 0.990
AEE95950.1
COGs: COG1453 oxidoreductase of the aldo/keto reductase family; InterPro IPR017896: IPR001395: IPR017900; KEGG: cth:Cthe_0236 aldo/keto reductase; PFAM: aldo/keto reductase; SPTR: Aldo/keto reductase; PFAM: Aldo/keto reductase family.
 
    0.840
AEE96016.1
Protein of unknown function DUF2088; COGs: COG3875 conserved hypothetical protein; InterPro IPR018657; KEGG: sno:Snov_3500 protein of unknown function DUF2088; PFAM: Protein of unknown function DUF2088; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2088).
 
  
 0.812
AEE95488.1
PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR011063: IPR012089; KEGG: ate:Athe_2599 PP-loop domain protein; PFAM: PP-loop domain protein; SPTR: PP-loop domain protein; PFAM: PP-loop family; Belongs to the TtcA family.
 
    0.805
AEE97842.1
Protein of unknown function DUF2088; COGs: COG3875 conserved hypothetical protein; InterPro IPR018657; KEGG: mta:Moth_1926 hypothetical protein; PFAM: Protein of unknown function DUF2088; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2088).
 
  
 0.800
mnmA
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
    
 0.758
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
    0.735
AEE95951.1
Transcriptional regulator, ArsR family; COGs: COG0640 transcriptional regulator protein; InterPro IPR001845; KEGG: mif:Metin_0066 transcriptional regulator, ArsR family; PFAM: regulatory protein ArsR; SMART: regulatory protein ArsR; SPTR: Transcriptional regulator, ArsR family; PFAM: Bacterial regulatory protein, arsR family.
       0.732
cbiM
Cobalamin (vitamin B12) biosynthesis CbiM protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
  
    0.575
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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