STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (345 aa)    
Predicted Functional Partners:
recX
Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.
  
 
 0.985
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.977
cinA
Competence/damage-inducible protein cinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR008135: IPR008136: IPR001453; KEGG: cth:Cthe_1052 competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; SPTR: Competence/damage-inducible protein CinA; TIGRFAM: competence/damage-inducible protein CinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal dom [...]
 
  
 0.943
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
 
 0.926
AEE97187.1
ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterPro IPR018329: IPR011545: IPR001650: IPR014021: IPR 014001; KEGG: caa:Caka_2440 ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: helicase domain protein; DEAD-like helicase; SPTR: ATP-dependent DNA helicase, RecQ family; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family.
  
 0.900
AEE95271.1
LexA DNA-binding domain protein; InterPro IPR006199; KEGG: ate:Athe_2440 transcriptional repressor, LexA family; PFAM: LexA DNA-binding domain protein; SPTR: LexA DNA binding domain protein; PFAM: LexA DNA binding domain.
  
 
 0.897
AEE96901.1
COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016: IPR014017: IPR000212: IPR005751; KEGG: tex:Teth514_0537 ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; SPTR: ATP-dependent DNA helicase PcrA; TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA.
  
 
 0.897
AEE98010.1
Transcriptional repressor, LexA family; COGs: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidase); InterPro IPR006199; KEGG: ate:Athe_2440 transcriptional repressor, LexA family; PFAM: LexA DNA-binding domain protein; SPTR: Transcriptional repressor, LexA family; PFAM: LexA DNA binding domain.
  
 
 0.897
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.877
AEE97550.1
LexA DNA-binding domain protein; InterPro IPR006199; KEGG: cwo:Cwoe_4471 transcriptional repressor, LexA family; PFAM: LexA DNA-binding domain protein; SPTR: LexA repressor; PFAM: LexA DNA binding domain.
  
 
 0.861
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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