node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEE96420.1 | AEE96427.1 | Mahau_1225 | Mahau_1233 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.703 |
AEE96420.1 | AEE96428.1 | Mahau_1225 | Mahau_1234 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878: IPR003043: IPR006362; KEGG: tmt:Tmath_0426 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.649 |
AEE96420.1 | AEE96429.1 | Mahau_1225 | Mahau_1235 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: slp:Slip_0922 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.753 |
AEE96420.1 | AEE96430.1 | Mahau_1225 | Mahau_1236 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: amt:Amet_0076 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.629 |
AEE96420.1 | AEE96433.1 | Mahau_1225 | Mahau_1239 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878: IPR003754: IPR003043: IPR006366; KEGG: pth:PTH_0973 uroporphyrinogen-III methylase and uroporphyrinogen-III synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.898 |
AEE96420.1 | AEE96434.1 | Mahau_1225 | Mahau_1240 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: pth:PTH_0975 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.478 |
AEE96420.1 | AEE96435.1 | Mahau_1225 | Mahau_1241 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: hmo:HM1_1963 siroheme synthase, N-terminal; SPTR: Siroheme synthase, n-terminal; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | 0.980 |
AEE96420.1 | hemA | Mahau_1225 | Mahau_1237 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.635 |
AEE96420.1 | hemC | Mahau_1225 | Mahau_1238 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.483 |
AEE96420.1 | hemL | Mahau_1225 | Mahau_1242 | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | Glutamate-1-semialdehyde-2,1-aminomutase; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814: IPR004639; KEGG: tmt:Tmath_0437 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; SPTR: Glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. | 0.475 |
AEE96427.1 | AEE96420.1 | Mahau_1233 | Mahau_1225 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: tjr:TherJR_1563 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX. | 0.703 |
AEE96427.1 | AEE96428.1 | Mahau_1233 | Mahau_1234 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878: IPR003043: IPR006362; KEGG: tmt:Tmath_0426 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.996 |
AEE96427.1 | AEE96429.1 | Mahau_1233 | Mahau_1235 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: slp:Slip_0922 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.994 |
AEE96427.1 | AEE96430.1 | Mahau_1233 | Mahau_1236 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: amt:Amet_0076 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.998 |
AEE96427.1 | AEE96433.1 | Mahau_1233 | Mahau_1239 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878: IPR003754: IPR003043: IPR006366; KEGG: pth:PTH_0973 uroporphyrinogen-III methylase and uroporphyrinogen-III synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Uroporphyrinogen-III methylase and Uroporphyrinogen-III synthase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.991 |
AEE96427.1 | AEE96434.1 | Mahau_1233 | Mahau_1240 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: pth:PTH_0975 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.808 |
AEE96427.1 | AEE96435.1 | Mahau_1233 | Mahau_1241 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: hmo:HM1_1963 siroheme synthase, N-terminal; SPTR: Siroheme synthase, n-terminal; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | 0.985 |
AEE96427.1 | hemA | Mahau_1233 | Mahau_1237 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.850 |
AEE96427.1 | hemC | Mahau_1233 | Mahau_1238 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.815 |
AEE96427.1 | hemL | Mahau_1233 | Mahau_1242 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: drm:Dred_2735 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | Glutamate-1-semialdehyde-2,1-aminomutase; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814: IPR004639; KEGG: tmt:Tmath_0437 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; SPTR: Glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. | 0.808 |