STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pyrFCOGs: COG0284 Orotidine-5'-phosphate decarboxylase; InterPro IPR001754: IPR018089: IPR011995; KEGG: cth:Cthe_0951 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; PRIAM: Orotidine-5'-phosphate decarboxylase; SPTR: Orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2; Belongs to the OMP decarboxylase family. Type 2 subfamily. (313 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.998
pyrR
Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
  
 
 0.995
pyrB
COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006132: IPR006131: IPR002082: IPR006130; KEGG: cce:Ccel_0612 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; SPTR: Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: ornithine carbamoyltransferase; aspar [...]
  
  
 0.990
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.988
carB
COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005481: IPR005479: IPR005480: IPR011607: IPR 005483: IPR011761: IPR006275; KEGG: cth:Cthe_0949 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: Carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MG [...]
  
 0.974
pyrD
Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.
 
  
 0.971
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
 
 0.952
carA
COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR001317: IPR011702: IPR006220: IPR017926: IPR 002474: IPR000991: IPR006274; KEGG: cce:Ccel_2913 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family.
 
  
 0.947
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.932
AEE96613.1
Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR001433: IPR019480: IPR012165: IPR017927; KEGG: cth:Cthe_0948 dihydroorotate oxidase B, electron transfer subunit; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; SPTR: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; PFAM: Iron-sulfur cluster bindi [...]
  
  
 0.922
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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