Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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cas1CRISPR-associated protein, Cas1 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (331 aa)    
Predicted Functional Partners:
cas2
CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 0.999
AEE97374.1
CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
 
 
 0.992
AEE95658.1
RNA-directed DNA polymerase (Reverse transcriptase); COGs: COG3344 Retron-type reverse transcriptase; InterPro IPR000123: IPR000477: IPR013597; KEGG: ere:EUBREC_2457 putative recombinase; PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron maturase-specific domain protein; SPTR: Putative uncharacterized protein; PFAM: Reverse transcriptase (RNA-dependent DNA polymerase); Group II intron, maturase-specific domain.
      0.901
AEE97375.1
CRISPR-associated helicase Cas3; COGs: COG1203 helicase; InterPro IPR014021: IPR001650: IPR006483: IPR006474; KEGG: dth:DICTH_0162 CRISPR-associated helicase Cas3; SPTR: CRISPR-associated helicase Cas3; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated HD domain protein; PFAM: DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD.
 
  
 0.897
AEE97379.1
CRISPR-associated protein Cas6; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
 
   
 0.854
AEE97377.1
CRISPR-associated protein, Csh2 family; COGs: COG3649 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR006482: IPR013419; KEGG: chy:CHY_2156 CRISPR-associated Csh2 family protein; PFAM: CRISPR-associated protein TM1801; SPTR: CRISPR-associated protein, Csh2 family; TIGRFAM: CRISPR-associated protein, Csh2 family; CRISPR-associated protein, CT1132 family; PFAM: Family of unknown function (DUF694); TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein, Csh2 family.
 
   
 0.853
AEE97376.1
CRISPR-associated protein Cas5; InterPro IPR013421: IPR013422; KEGG: chy:CHY_2155 CRISPR-associated Cas5 family Hmari subtype protein; SPTR: CRISPR-associated protein Cas5, Hmari subtype; TIGRFAM: CRISPR-associated protein Cas5; CRISPR-associated protein Cas5, Hmari subtype; PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, Hmari subtype; CRISPR-associated protein Cas5, N-terminal domain.
 
   
 0.828
AEE97378.1
InterPro IPR013389: IPR013420; KEGG: chy:CHY_2157 CRISPR-associated Csh1 family protein; PFAM: CRISPR-associated protein TM1802; SPTR: CRISPR-associated protein, Csh1 family; TIGRFAM: CRISPR-associated protein, Csh1 family; CRISPR-associated protein, TM1802 family; PFAM: CRISPR-associated protein TM1802 (cas_TM1802); TIGRFAM: CRISPR-associated protein, TM1802 family; CRISPR-associated protein, Csh1 family.
 
     0.753
AEE96001.1
COGs: COG0776 Bacterial nucleoid DNA-binding protein; InterPro IPR000119; KEGG: tte:TTE2453 nucleoid DNA-binding protein; PFAM: histone family protein DNA-binding protein; SMART: histone family protein DNA-binding protein; SPTR: Bacterial nucleoid DNA-binding protein; PFAM: Bacterial DNA-binding protein; Belongs to the bacterial histone-like protein family.
    
 
 0.627
ruvC
Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
      
 0.448
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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