STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGW21907.1PFAM: Protein of unknown function DUF62; KEGG: mca:MCA1485 hypothetical protein. (249 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
  0.825
ttcA
tRNA 2-thiocytidine biosynthesis protein TtcA; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
       0.773
cmk
TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: mca:MCA1414 cytidylate kinase; PFAM: Cytidylate kinase region.
 
  
  0.585
EGW23195.1
Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
  0.571
EGW21905.1
KEGG: mca:MCA2879 3-oxoacyl-(acyl-carrier-protein) synthase I; PFAM: Beta-ketoacyl synthase, N-terminal; Beta-ketoacyl synthase, C-terminal; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
       0.566
fabA
3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
       0.552
EGW21852.1
TIGRFAM: Adenylosuccinate lyase; KEGG: tgr:Tgr7_1849 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
  0.530
EGW22773.1
Uracil phosphoribosyltransferase; KEGG: mca:MCA2334 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; PFAM: Phosphoribosyltransferase.
    
  0.522
purH
Bifunctional purine biosynthesis protein purH; KEGG: maq:Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region.
    
  0.514
EGW22666.1
PFAM: Pyrimidine nucleoside phosphorylase, C-terminal; Glycosyl transferase, family 3, N-terminal; TIGRFAM: Thymidine phosphorylase related; HAMAP: Thymidine phosphorylase related; KEGG: mca:MCA1717 thymidine phosphorylase.
    
  0.513
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.