| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Mettu_0644 | glyA | Mettu_0644 | Mettu_1433 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | 0.808 |
| Mettu_0644 | guaA | Mettu_0644 | Mettu_1868 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.960 |
| Mettu_0644 | guaB | Mettu_0644 | Mettu_1869 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.849 |
| Mettu_0644 | purA | Mettu_0644 | Mettu_2976 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family | 0.998 |
| Mettu_0644 | purC | Mettu_0644 | Mettu_1687 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | PFAM- SAICAR synthetase; TIGRFAM- SAICAR synthetase; HAMAP- Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG- mca-MCA0021 phosphoribosylaminoimidazole-succinocarboxamide synthase | 0.998 |
| Mettu_0644 | purD | Mettu_0644 | Mettu_2625 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Phosphoribosylamine--glycine ligase; PFAM- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM- Phosphoribosylglycinamide synthetase; HAMAP- Phosphoribosylglycinamide synthetase; KEGG- mca-MCA0361 phosphoribosylamine--glycine ligase; Belongs to the GARS family | 0.987 |
| Mettu_0644 | purF | Mettu_0644 | Mettu_0895 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family | 0.933 |
| Mettu_0644 | purH | Mettu_0644 | Mettu_2626 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Bifunctional purine biosynthesis protein PurH; KEGG- maq-Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM- AICARFT/IMPCHase bienzyme; HAMAP- Bifunctional purine biosynthesis protein purH; SMART- AICARFT/IMPCHase bienzyme, formylation region | 0.998 |
| Mettu_0644 | purL | Mettu_0644 | Mettu_3166 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.992 |
| Mettu_0644 | purM | Mettu_0644 | Mettu_1198 | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | TIGRFAM- Phosphoribosylformylglycinamidine cyclo-ligase; KEGG- mca-MCA0373 phosphoribosylaminoimidazole synthetase; PFAM- AIR synthase related protein, C-terminal; AIR synthase related protein | 0.670 |
| glyA | Mettu_0644 | Mettu_1433 | Mettu_0644 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | 0.808 |
| glyA | guaA | Mettu_1433 | Mettu_1868 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | 0.847 |
| glyA | guaB | Mettu_1433 | Mettu_1869 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family | 0.705 |
| glyA | purA | Mettu_1433 | Mettu_2976 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family | 0.610 |
| glyA | purC | Mettu_1433 | Mettu_1687 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | PFAM- SAICAR synthetase; TIGRFAM- SAICAR synthetase; HAMAP- Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG- mca-MCA0021 phosphoribosylaminoimidazole-succinocarboxamide synthase | 0.922 |
| glyA | purD | Mettu_1433 | Mettu_2625 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Phosphoribosylamine--glycine ligase; PFAM- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM- Phosphoribosylglycinamide synthetase; HAMAP- Phosphoribosylglycinamide synthetase; KEGG- mca-MCA0361 phosphoribosylamine--glycine ligase; Belongs to the GARS family | 0.937 |
| glyA | purF | Mettu_1433 | Mettu_0895 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family | 0.735 |
| glyA | purH | Mettu_1433 | Mettu_2626 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Bifunctional purine biosynthesis protein PurH; KEGG- maq-Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM- AICARFT/IMPCHase bienzyme; HAMAP- Bifunctional purine biosynthesis protein purH; SMART- AICARFT/IMPCHase bienzyme, formylation region | 0.983 |
| glyA | purL | Mettu_1433 | Mettu_3166 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.936 |
| guaA | Mettu_0644 | Mettu_1868 | Mettu_0644 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP | TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | 0.960 |
