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purH protein (Methylobacter tundripaludum) - STRING interaction network
"purH" - Bifunctional purine biosynthesis protein PurH in Methylobacter tundripaludum
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
purHBifunctional purine biosynthesis protein PurH; KEGG- maq-Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM- AICARFT/IMPCHase bienzyme; HAMAP- Bifunctional purine biosynthesis protein purH; SMART- AICARFT/IMPCHase bienzyme, formylation region (535 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1289 aa)
   
  0.999
Mettu_0644
TIGRFAM- Adenylosuccinate lyase; KEGG- tgr-Tgr7_1849 adenylosuccinate lyase; PFAM- Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (454 aa)
   
  0.998
purD
Phosphoribosylamine--glycine ligase; PFAM- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM- Phosphoribosylglycinamide synthetase; HAMAP- Phosphoribosylglycinamide synthetase; KEGG- mca-MCA0361 phosphoribosylamine--glycine ligase; Belongs to the GARS family (426 aa)
 
  0.997
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family (502 aa)
 
  0.985
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
   
  0.983
purM
TIGRFAM- Phosphoribosylformylglycinamidine cyclo-ligase; KEGG- mca-MCA0373 phosphoribosylaminoimidazole synthetase; PFAM- AIR synthase related protein, C-terminal; AIR synthase related protein (347 aa)
 
 
  0.981
purC
PFAM- SAICAR synthetase; TIGRFAM- SAICAR synthetase; HAMAP- Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG- mca-MCA0021 phosphoribosylaminoimidazole-succinocarboxamide synthase (297 aa)
   
  0.980
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (430 aa)
 
  0.978
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (488 aa)
 
  0.977
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (528 aa)
 
   
  0.974
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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