| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGW20080.1 | EGW20622.1 | Mettu_3206 | Mettu_3769 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.579 |
| EGW20080.1 | EGW22400.1 | Mettu_3206 | Mettu_1214 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Multi-sensor hybrid histidine kinase; KEGG: dat:HRM2_43550 putative two-component system sensor protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, phosphotransfer (Hpt) region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; Signal transduction response regulator, receiver region. | 0.584 |
| EGW20080.1 | aroE | Mettu_3206 | Mettu_2538 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.575 |
| EGW20080.1 | csrA | Mettu_3206 | Mettu_4080 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Carbon storage regulator, CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | 0.535 |
| EGW20080.1 | hfq | Mettu_3206 | Mettu_2981 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.535 |
| EGW20080.1 | infA | Mettu_3206 | Mettu_0639 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | 0.572 |
| EGW20080.1 | nadD | Mettu_3206 | Mettu_1022 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.867 |
| EGW20080.1 | rlmE | Mettu_3206 | Mettu_3205 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.707 |
| EGW20080.1 | rplK | Mettu_3206 | Mettu_1345 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.860 |
| EGW20080.1 | rsfS | Mettu_3206 | Mettu_1023 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.704 |
| EGW20622.1 | EGW20080.1 | Mettu_3769 | Mettu_3206 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | 0.579 |
| EGW20622.1 | EGW22400.1 | Mettu_3769 | Mettu_1214 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Multi-sensor hybrid histidine kinase; KEGG: dat:HRM2_43550 putative two-component system sensor protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, phosphotransfer (Hpt) region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; Signal transduction response regulator, receiver region. | 0.576 |
| EGW20622.1 | aroE | Mettu_3769 | Mettu_2538 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.425 |
| EGW20622.1 | csrA | Mettu_3769 | Mettu_4080 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Carbon storage regulator, CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | 0.533 |
| EGW20622.1 | hfq | Mettu_3769 | Mettu_2981 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.539 |
| EGW20622.1 | rlmE | Mettu_3769 | Mettu_3205 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.890 |
| EGW20622.1 | rplK | Mettu_3769 | Mettu_1345 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.763 |
| EGW20622.1 | rsfS | Mettu_3769 | Mettu_1023 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.701 |
| EGW22400.1 | EGW20080.1 | Mettu_1214 | Mettu_3206 | Multi-sensor hybrid histidine kinase; KEGG: dat:HRM2_43550 putative two-component system sensor protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, phosphotransfer (Hpt) region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; Signal transduction response regulator, receiver region. | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: aeh:Mlg_1978 hypothetical protein. | 0.584 |
| EGW22400.1 | EGW20622.1 | Mettu_1214 | Mettu_3769 | Multi-sensor hybrid histidine kinase; KEGG: dat:HRM2_43550 putative two-component system sensor protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, phosphotransfer (Hpt) region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; Signal transduction response regulator, receiver region. | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.576 |