Ttc1 protein (Blattella germanica) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

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Score

Ttc1

Tetratricopeptide repeat protein 1. (226 aa)

Predicted Functional Partners:

rnf41

0.756

PPP1R7_0

0.589

PPP1R7_1

0.589

VAPA

0.558

C0J52_06655

0.549

HSPA4

0.527

SUGT1

0.493

C0J52_03408

0.437

Hsp83

0.415

HSP90AA1

0.415

Your Current Organism:

Blattella germanica

NCBI taxonomy Id: 6973
Other names: B. germanica, German cockroach

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C0J52_03408	HSP90AA1	A0A2P8YVN5	A0A2P8ZIM3	Uncharacterized protein.	Heat shock protein HSP 90-alpha.	0.743
C0J52_03408	HSPA4	A0A2P8YVN5	A0A2P8XRA4	Uncharacterized protein.	Heat shock 70 kDa protein 4.	0.478
C0J52_03408	Hsp83	A0A2P8YVN5	A0A2P8YNI5	Uncharacterized protein.	Heat shock protein 83.	0.743
C0J52_03408	Ttc1	A0A2P8YVN5	A0A2P8XGB7	Uncharacterized protein.	Tetratricopeptide repeat protein 1.	0.437
C0J52_06655	HSP90AA1	A0A2P8Z114	A0A2P8ZIM3	Uncharacterized protein.	Heat shock protein HSP 90-alpha.	0.894
C0J52_06655	HSPA4	A0A2P8Z114	A0A2P8XRA4	Uncharacterized protein.	Heat shock 70 kDa protein 4.	0.635
C0J52_06655	Hsp83	A0A2P8Z114	A0A2P8YNI5	Uncharacterized protein.	Heat shock protein 83.	0.894
C0J52_06655	Ttc1	A0A2P8Z114	A0A2P8XGB7	Uncharacterized protein.	Tetratricopeptide repeat protein 1.	0.549
C0J52_06655	rnf41	A0A2P8Z114	A0A2P8XFY7	Uncharacterized protein.	E3 ubiquitin-protein ligase NRDP1.	0.573
HSP90AA1	C0J52_03408	A0A2P8ZIM3	A0A2P8YVN5	Heat shock protein HSP 90-alpha.	Uncharacterized protein.	0.743
HSP90AA1	C0J52_06655	A0A2P8ZIM3	A0A2P8Z114	Heat shock protein HSP 90-alpha.	Uncharacterized protein.	0.894
HSP90AA1	HSPA4	A0A2P8ZIM3	A0A2P8XRA4	Heat shock protein HSP 90-alpha.	Heat shock 70 kDa protein 4.	0.955
HSP90AA1	SUGT1	A0A2P8ZIM3	A0A2P8YU91	Heat shock protein HSP 90-alpha.	Protein SGT1.	0.980
HSP90AA1	Ttc1	A0A2P8ZIM3	A0A2P8XGB7	Heat shock protein HSP 90-alpha.	Tetratricopeptide repeat protein 1.	0.415
HSPA4	C0J52_03408	A0A2P8XRA4	A0A2P8YVN5	Heat shock 70 kDa protein 4.	Uncharacterized protein.	0.478
HSPA4	C0J52_06655	A0A2P8XRA4	A0A2P8Z114	Heat shock 70 kDa protein 4.	Uncharacterized protein.	0.635
HSPA4	HSP90AA1	A0A2P8XRA4	A0A2P8ZIM3	Heat shock 70 kDa protein 4.	Heat shock protein HSP 90-alpha.	0.955
HSPA4	Hsp83	A0A2P8XRA4	A0A2P8YNI5	Heat shock 70 kDa protein 4.	Heat shock protein 83.	0.955
HSPA4	Ttc1	A0A2P8XRA4	A0A2P8XGB7	Heat shock 70 kDa protein 4.	Tetratricopeptide repeat protein 1.	0.527
Hsp83	C0J52_03408	A0A2P8YNI5	A0A2P8YVN5	Heat shock protein 83.	Uncharacterized protein.	0.743

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.776

expected number of edges:

13

PPI enrichment p-value:

0.000137

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006596

Polyamine biosynthetic process

6 of 25

3.01

6.95

1.07e-13

GO:0006591

Ornithine metabolic process

5 of 14

3.18

6.26

3.26e-12

GO:0006525

Arginine metabolic process

5 of 20

3.02

5.9

1.19e-11

GO:1901605

Alpha-amino acid metabolic process

9 of 321

2.07

5.54

1.97e-14

GO:0009446

Putrescine biosynthetic process

4 of 8

3.32

5.14

4.61e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016813

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

5 of 16

3.12

5.87

1.61e-11

GO:0004053

Arginase activity

3 of 3

3.63

3.62

3.05e-07

GO:0008783

Agmatinase activity

2 of 2

3.63

2.01

0.00024

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

2 of 4

3.32

1.89

0.00039

GO:0004586

Ornithine decarboxylase activity

2 of 5

3.23

1.88

0.00041

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:3761021

(1986) Urea cycle activity and arginine formation in rainbow trout (Salmo gairdneri)

3 of 3

3.63

3.43

6.78e-07

PMID:29238889

(2018) Immunomodulatory effects of Rhodomyrtus tomentosa leaf extract and its derivative compound, rhodomyrtone, on head kidney macrophages of rainbow trout (Oncorhynchus mykiss).

3 of 3

3.63

3.43

6.78e-07

PMID:26600157

(2015) Widespread Natural Occurrence of Hydroxyurea in Animals.

3 of 3

3.63

3.43

6.78e-07

PMID:34578212

(2021) Intestinal Transcriptomic and Histologic Profiling Reveals Tissue Repair Mechanisms Underlying Resistance to the Parasite Ceratonova shasta.

3 of 5

3.4

3.42

6.78e-07

PMID:34201988

(2021) Post-Prandial Amino Acid Changes in Gilthead Sea Bream.

3 of 5

3.4

3.42

6.78e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:55228

Arginase, and Agmatinase activity

5 of 5

3.63

6.76

5.91e-13

CL:57371

Polyamine biosynthetic process, and UDP-N-acetylglucosamine biosynthetic process

3 of 34

2.57

2.19

8.74e-05

CL:60604

Mixed, incl. S-methyl-5-thioadenosine phosphorylase activity, and Spermine synthase, animal

2 of 6

3.15

1.57

0.0015

CL:57417

Ornithine decarboxylase, and Ornithine decarboxylase antizyme

2 of 6

3.15

1.57

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00330

Arginine and proline metabolism

9 of 199

2.28

7.41

6.59e-18

map00270

Cysteine and methionine metabolism

4 of 157

2.03

2.64

2.98e-06

map00220

Arginine biosynthesis

3 of 73

2.24

2.3

3.42e-05

map00480

Glutathione metabolism

3 of 194

1.81

1.59

0.00048

map01230

Biosynthesis of amino acids

3 of 278

1.66

1.35

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-351143

Agmatine biosynthesis

4 of 4

3.63

5.54

1.00e-10

MAP-71291

Metabolism of amino acids and derivatives

11 of 664

1.84

5.28

9.44e-18

MAP-351202

Metabolism of polyamines

6 of 153

2.22

4.43

3.73e-10

MAP-70635

Urea cycle

3 of 11

3.06

3.25

1.21e-06

MAP-1237112

Methionine salvage pathway

2 of 6

3.15

1.88

0.00040

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0835

Urea cycle

3 of 3

3.63

3.98

6.89e-08

KW-0056

Arginine metabolism

3 of 3

3.63

3.98

6.89e-08

KW-0620

Polyamine biosynthesis

2 of 4

3.32

2.25

8.65e-05

KW-0464

Manganese

3 of 75

2.23

2.1

8.65e-05

KW-0378

Hydrolase

4 of 950

1.25

0.94

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00491

Arginase family

4 of 4

3.63

5.2

4.09e-10

PF02784

Pyridoxal-dependent decarboxylase, pyridoxal binding domain

2 of 5

3.23

1.52

0.0018

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020855

Ureohydrolase, manganese-binding site

4 of 4

3.63

4.95

1.19e-09

IPR006035

Ureohydrolase

4 of 4

3.63

4.95

1.19e-09

IPR023696

Ureohydrolase domain superfamily

4 of 30

2.75

3.54

2.61e-07

IPR014033

Arginase

3 of 3

3.63

3.5

4.92e-07

IPR022657

Orn/DAP/Arg decarboxylase 2, conserved site

2 of 3

3.45

1.67

0.0010

(more ...)

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