DYRK2 protein (Blattella germanica) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

DYRK2

Dual specificity tyrosine-phosphorylation-regulated kinase 2. (583 aa)

Predicted Functional Partners:

C0J52_13017

0.701

sumo3

0.694

ube2i

0.690

Dcaf7_2

0.687

Dcaf7_0

0.687

Dcaf7_3

0.687

Dcaf7_1

0.687

lin52

0.682

C0J52_07824

0.676

dod

0.659

Your Current Organism:

Blattella germanica

NCBI taxonomy Id: 6973
Other names: B. germanica, German cockroach

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C0J52_07824	C0J52_13017	A0A2P8XQT8	A0A2P8YCU9	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.713
C0J52_07824	DYRK2	A0A2P8XQT8	A0A2P8XTB8	Uncharacterized protein.	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	0.676
C0J52_07824	sumo3	A0A2P8XQT8	A0A2P8YTZ1	Uncharacterized protein.	Small ubiquitin-related modifier 3.	0.517
C0J52_07824	ube2i	A0A2P8XQT8	A0A2P8XQY0	Uncharacterized protein.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.712
C0J52_13017	C0J52_07824	A0A2P8YCU9	A0A2P8XQT8	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.713
C0J52_13017	DYRK2	A0A2P8YCU9	A0A2P8XTB8	Ubiquitin-like domain-containing protein.	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	0.701
C0J52_13017	sumo3	A0A2P8YCU9	A0A2P8YTZ1	Ubiquitin-like domain-containing protein.	Small ubiquitin-related modifier 3.	0.960
C0J52_13017	ube2i	A0A2P8YCU9	A0A2P8XQY0	Ubiquitin-like domain-containing protein.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.999
DYRK2	C0J52_07824	A0A2P8XTB8	A0A2P8XQT8	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	Uncharacterized protein.	0.676
DYRK2	C0J52_13017	A0A2P8XTB8	A0A2P8YCU9	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	Ubiquitin-like domain-containing protein.	0.701
DYRK2	Dcaf7_0	A0A2P8XTB8	A0A2P8ZCV8	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	DDB1-and CUL4-associated factor 7.	0.687
DYRK2	Dcaf7_1	A0A2P8XTB8	A0A2P8ZCW2	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	DDB1-and CUL4-associated factor 7.	0.687
DYRK2	Dcaf7_2	A0A2P8XTB8	A0A2P8YLS6	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	DDB1-and CUL4-associated factor 7.	0.687
DYRK2	Dcaf7_3	A0A2P8XTB8	A0A2P8ZCV9	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	DDB1-and CUL4-associated factor 7.	0.687
DYRK2	dod	A0A2P8XTB8	A0A2P8YAL7	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	Peptidyl-prolyl cis-trans isomerase.	0.659
DYRK2	lin52	A0A2P8XTB8	A0A2P8Z0J2	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	Protein lin-52.	0.682
DYRK2	sumo3	A0A2P8XTB8	A0A2P8YTZ1	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	Small ubiquitin-related modifier 3.	0.694
DYRK2	ube2i	A0A2P8XTB8	A0A2P8XQY0	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.690
Dcaf7_0	DYRK2	A0A2P8ZCV8	A0A2P8XTB8	DDB1-and CUL4-associated factor 7.	Dual specificity tyrosine-phosphorylation-regulated kinase 2.	0.687
Dcaf7_0	Dcaf7_1	A0A2P8ZCV8	A0A2P8ZCW2	DDB1-and CUL4-associated factor 7.	DDB1-and CUL4-associated factor 7.	0.907

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

92

PPI enrichment p-value:

0.665

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016989

Sigma factor antagonist activity

3 of 5

2.41

1.96

0.00021

GO:0015343

Siderophore transmembrane transporter activity

3 of 13

2.0

1.56

0.00085

GO:0060089

Molecular transducer activity

5 of 63

1.53

0.00019

GO:0031992

Energy transducer activity

2 of 2

2.63

1.31

0.0040

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031224

Intrinsic component of membrane

10 of 1169

0.56

0.45

0.0012

GO:0016021

Integral component of membrane

9 of 1162

0.52

0.39

0.0059

GO:0016020

Membrane

11 of 1689

0.45

0.37

0.0012

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36618666

(2022) Responses of the bacterial community of tobacco phyllosphere to summer climate and wildfire disease.

2 of 2

2.63

1.3

0.0042

PMID:36677491

(2023) Sphingomonas sediminicola Is an Endosymbiotic Bacterium Able to Induce the Formation of Root Nodules in Pea (Pisum sativum L.) and to Enhance Plant Biomass Production.

3 of 17

1.88

1.27

0.0030

PMID:24319357

(2013) Engineering rhizobial bioinoculants: a strategy to improve iron nutrition.

2 of 12

1.85

0.72

0.0421

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:979

Mixed, incl. Protein insertion into membrane, and Energy transducer activity

6 of 20

2.11

3.76

7.50e-09

CL:981

Mixed, incl. Energy transducer activity, and Biopolymer transport protein ExbD/TolR

5 of 12

2.25

3.51

7.98e-08

CL:995

Mixed, incl. Energy transducer activity, and Biopolymer transport protein ExbD/TolR

4 of 5

2.54

3.3

5.52e-07

CL:5671

FecR protein, and TonB-dependent siderophore receptor

4 of 10

2.23

2.76

3.49e-06

CL:5675

FecR protein, and Secretin/TonB, short N-terminal domain

3 of 5

2.41

2.2

7.24e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005887

Integral component of plasma membrane

4 of 87

1.29

0.81

0.0125

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16220

Domain of unknown function (DUF4880)

3 of 3

2.63

2.12

0.00012

PF04773

FecR protein

3 of 3

2.63

2.12

0.00012

PF03544

Gram-negative bacterial TonB protein C-terminal

2 of 3

2.46

1.08

0.0107

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR032623

FecR, N-terminal

3 of 3

2.63

1.9

0.00032

IPR012373

Fe(2+)-dicitrate sensor, transmembrane component

3 of 3

2.63

1.9

0.00032

IPR006860

FecR protein

3 of 3

2.63

1.9

0.00032

IPR006260

TonB/TolA, C-terminal

2 of 3

2.46

0.92

0.0213

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