STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ptpn4Tyrosine-protein phosphatase non-receptor type 4. (653 aa)    
Predicted Functional Partners:
C0J52_12889
Uncharacterized protein.
    
 
 0.846
lrk-1
Leucine-rich repeat serine/threonine-protein kinase 1.
    
 0.838
Mpk2
Mitogen-activated protein kinase 14A.
    
 0.803
p38b
Mitogen-activated protein kinase 14B.
    
 0.803
drk
Protein E(Sev)2B.
   
 0.797
Egfr
Epidermal growth factor receptor.
    
 0.792
MAPK1
Mitogen-activated protein kinase 1.
    
 0.778
C0J52_02446
Uncharacterized protein.
    
  0.773
C0J52_07900
Protein kinase domain-containing protein.
    
 0.762
C0J52_01205
Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
    
 0.745
Your Current Organism:
Blattella germanica
NCBI taxonomy Id: 6973
Other names: B. germanica, German cockroach
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