STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATICBifunctional purine biosynthesis protein PURH. (571 aa)    
Predicted Functional Partners:
SHMT1
Serine hydroxymethyltransferase.
  
 0.999
GART
Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.
 
 0.999
ADSL
Adenylosuccinate lyase.
  
 0.999
Prat
Amidophosphoribosyltransferase.
  
 0.998
C1TC
C-1-tetrahydrofolate synthase.
  
 0.997
C0J52_14852
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
  
 0.995
Aprt
Adenine phosphoribosyltransferase.
  
 0.983
C0J52_22160
THF_DHG_CYH domain-containing protein.
  
 
 0.981
MTHFD2
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase.
  
 
 0.981
IMPDH1
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
  
 
 0.978
Your Current Organism:
Blattella germanica
NCBI taxonomy Id: 6973
Other names: B. germanica, German cockroach
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