DNAH5_3 protein (Blattella germanica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DNAH5_3

Dynein heavy chain 5. (340 aa)

Predicted Functional Partners:

DNAH5_0

0.951

C0J52_27232

0.950

DNAH8_0

0.950

Dnah5_1

0.949

DNAH8_3

0.946

DNAH6_5

0.934

DNAH8_2

0.928

DNAH10_1

0.925

DNAH6_0

0.924

DNAH6_3

0.920

Your Current Organism:

Blattella germanica

NCBI taxonomy Id: 6973
Other names: B. germanica, German cockroach

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C0J52_27232	DNAH10_1	A0A2P8XBB6	A0A2P8Z924	Uncharacterized protein.	Dynein heavy chain 10.	0.923
C0J52_27232	DNAH5_0	A0A2P8XBB6	A0A2P8ZCK6	Uncharacterized protein.	Dynein heavy chain 5.	0.951
C0J52_27232	DNAH5_3	A0A2P8XBB6	A0A2P8ZCK2	Uncharacterized protein.	Dynein heavy chain 5.	0.950
C0J52_27232	DNAH6_3	A0A2P8XBB6	A0A2P8XYP7	Uncharacterized protein.	Dynein heavy chain 6.	0.459
C0J52_27232	DNAH6_5	A0A2P8XBB6	A0A2P8XYG4	Uncharacterized protein.	Dynein heavy chain 6.	0.927
C0J52_27232	DNAH8_2	A0A2P8XBB6	A0A2P8ZCG9	Uncharacterized protein.	Dynein heavy chain 8.	0.942
C0J52_27232	DNAH8_3	A0A2P8XBB6	A0A2P8ZCG1	Uncharacterized protein.	Dynein heavy chain 8.	0.950
DNAH10_1	C0J52_27232	A0A2P8Z924	A0A2P8XBB6	Dynein heavy chain 10.	Uncharacterized protein.	0.923
DNAH10_1	DNAH5_3	A0A2P8Z924	A0A2P8ZCK2	Dynein heavy chain 10.	Dynein heavy chain 5.	0.925
DNAH10_1	DNAH6_0	A0A2P8Z924	A0A2P8XYE2	Dynein heavy chain 10.	Dynein heavy chain 6.	0.934
DNAH10_1	DNAH8_0	A0A2P8Z924	A0A2P8ZCI8	Dynein heavy chain 10.	Dynein heavy chain 8.	0.898
DNAH10_1	Dnah5_1	A0A2P8Z924	A0A2P8ZCK1	Dynein heavy chain 10.	Dynein heavy chain 5.	0.922
DNAH5_0	C0J52_27232	A0A2P8ZCK6	A0A2P8XBB6	Dynein heavy chain 5.	Uncharacterized protein.	0.951
DNAH5_0	DNAH5_3	A0A2P8ZCK6	A0A2P8ZCK2	Dynein heavy chain 5.	Dynein heavy chain 5.	0.951
DNAH5_0	DNAH6_0	A0A2P8ZCK6	A0A2P8XYE2	Dynein heavy chain 5.	Dynein heavy chain 6.	0.916
DNAH5_0	DNAH8_0	A0A2P8ZCK6	A0A2P8ZCI8	Dynein heavy chain 5.	Dynein heavy chain 8.	0.950
DNAH5_0	DNAH8_2	A0A2P8ZCK6	A0A2P8ZCG9	Dynein heavy chain 5.	Dynein heavy chain 8.	0.940
DNAH5_0	DNAH8_3	A0A2P8ZCK6	A0A2P8ZCG1	Dynein heavy chain 5.	Dynein heavy chain 8.	0.950
DNAH5_0	Dnah5_1	A0A2P8ZCK6	A0A2P8ZCK1	Dynein heavy chain 5.	Dynein heavy chain 5.	0.950
DNAH5_3	C0J52_27232	A0A2P8ZCK2	A0A2P8XBB6	Dynein heavy chain 5.	Uncharacterized protein.	0.950

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.885

expected number of edges:

11

PPI enrichment p-value:

0.000195

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001732

Formation of cytoplasmic translation initiation complex

10 of 16

2.95

12.23

1.43e-24

GO:0006446

Regulation of translational initiation

3 of 19

2.35

2.27

4.70e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

11 of 44

2.55

11.02

6.93e-25

GO:0031369

Translation initiation factor binding

2 of 20

2.15

0.89

0.0217

GO:0003723

RNA binding

5 of 678

1.02

0.65

0.0139

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033290

Eukaryotic 48S preinitiation complex

11 of 15

3.02

14.64

2.50e-29

GO:0005852

Eukaryotic translation initiation factor 3 complex

10 of 14

3.0

13.14

3.29e-26

GO:0016282

Eukaryotic 43S preinitiation complex

10 of 18

2.9

12.54

1.65e-25

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7924

Translation preinitiation complex

11 of 20

2.89

13.62

6.42e-28

CL:7926

Eukaryotic translation initiation factor 3 complex

10 of 12

3.07

13.34

2.54e-26

CL:7938

Eukaryotic translation initiation factor 3 complex

5 of 6

3.07

5.93

1.15e-11

CL:7927

Eukaryotic translation initiation factor 3 complex

5 of 6

3.07

5.93

1.15e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

9 of 180

1.85

4.61

4.04e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

11 of 49

2.5

10.67

1.46e-24

MAP-72649

Translation initiation complex formation

11 of 56

2.44

10.29

2.74e-24

MAP-72702

Ribosomal scanning and start codon recognition

11 of 58

2.43

10.21

2.74e-24

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

11 of 59

2.42

10.17

2.74e-24

MAP-156827

L13a-mediated translational silencing of Ceruloplasmin expression

11 of 102

2.18

8.15

4.95e-22

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

9 of 13

2.99

11.24

2.49e-22

GOCC:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

3 of 4

3.03

2.86

6.15e-06

GOCC:0071540

Eukaryotic translation initiation factor 3 complex, eIF3e

2 of 2

3.15

1.74

0.00073

GOCC:0043614

multi-eIF complex

2 of 2

3.15

1.74

0.00073

GOCC:0070993

Translation preinitiation complex

2 of 4

2.85

1.59

0.0013

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

8 of 19

2.77

9.11

1.14e-18

KW-0963

Cytoplasm

8 of 161

1.85

4.21

2.32e-12

KW-0694

RNA-binding

3 of 191

1.35

0.76

0.0194

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000717

Proteasome component (PCI) domain

4 of 18

2.5

2.87

3.75e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

3 of 13

2.51

2.21

7.67e-05

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