Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEM77610.1PFAM: Methyladenine glycosylase; KEGG: tbo:Thebr_2200 DNA-3-methyladenine glycosylase I. (190 aa)    
Predicted Functional Partners:
AEM77609.1
KEGG: tbo:Thebr_2201 glucokinase, ROK family; TIGRFAM: Glucokinase ROK; PFAM: ROK.
       0.766
AEM79859.1
Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
   
 0.731
polA
5'-3' exonuclease, resolvase-like domain-containing protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.635
AEM77611.1
PFAM: Sigma-G inhibitor, Gin; KEGG: tbo:Thebr_2199 sigma-G inhibitor, Gin.
       0.480
cinA
KEGG: tbo:Thebr_1221 competence/damage-inducible protein CinA; TIGRFAM: Competence-induced protein CinA; CinA, C-terminal; PFAM: CinA, C-terminal; Molybdopterin binding; Belongs to the CinA family.
  
    0.453
AEM77608.1
KEGG: tpd:Teth39_2037 RNA-directed DNA polymerase (reverse transcriptase).
       0.443
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
       0.411
AEM77614.1
PFAM: Protein of unknown function DUF970; KEGG: tbo:Thebr_2196 hypothetical protein.
       0.401
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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