Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEM77626.1KEGG: tbo:Thebr_2188 AbrB family transcriptional regulator; TIGRFAM: Transcription regulator AbrB; PFAM: Transcription regulator AbrB/SpoV, predicted. (83 aa)    
Predicted Functional Partners:
AEM78676.1
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.808
AEM77684.1
TIGRFAM: Sporulation stage III, transcriptional regulator SpoIIID; KEGG: tbo:Thebr_2141 sporulation transcriptional regulator SpoIIID.
  
   
 0.746
AEM78657.1
KEGG: tbo:Thebr_1117 stage III sporulation protein AC; TIGRFAM: Sporulation stage III, protein AC; PFAM: Sporulation stage III, protein AC.
  
   
 0.717
AEM78977.1
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.697
AEM79668.1
PFAM: Bacillus/Clostridium GerA spore germination protein; KEGG: tbo:Thebr_0321 GerA spore germination protein.
  
   
 0.658
AEM79792.1
KEGG: tbo:Thebr_0259 sporulation protein YabP; TIGRFAM: Sporulation protein YabP; PFAM: Sporulation protein YabP.
  
   
 0.649
spoIIAB
Anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.648
AEM77628.1
PFAM: Nucleoside recognition; KEGG: tbo:Thebr_2186 nucleoside recognition domain-containing protein.
     
 0.645
AEM77627.1
PFAM: Nucleoside recognition; KEGG: thx:Thet_0098 nucleoside recognition domain-containing protein.
     
 0.643
AEM78692.1
KEGG: tbo:Thebr_1152 stage V sporulation protein AC; TIGRFAM: Sporulation stage V, protein AC; PFAM: SpoVA.
  
     0.606
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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