Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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prmCprotein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (279 aa)    
Predicted Functional Partners:
prfA
Hypothetical protein; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
 
 0.993
AEM77661.1
PFAM: Protein of unknown function DUF1385; KEGG: tbo:Thebr_2158 hypothetical protein.
     0.982
AEM77665.1
Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
 
  
 0.945
tdk
KEGG: tbo:Thebr_2159 thymidine kinase; HAMAP: Thymidine kinase, subgroup; PFAM: Thymidine kinase.
  
  
 0.827
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
     
 0.721
atpH
ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
 
   0.684
rho
Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
       0.651
AEM78372.1
UPF0340 protein; TIGRFAM: Conserved hypothetical protein CHP01440; HAMAP: UPF0340 protein; KEGG: tbo:Thebr_1514 hypothetical protein; PFAM: Conserved hypothetical protein CHP01440; Belongs to the UPF0340 family.
      0.640
atpE
ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
  
   0.635
AEM77666.1
Sugar-phosphate isomerase, RpiB/LacA/LacB family; TIGRFAM: Ribose/galactose isomerase; Ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; Protein-tyrosine phosphatase, low molecular weight; KEGG: tit:Thit_0129 sugar-phosphate isomerase, RpiB/LacA/LacB family; SMART: Protein-tyrosine phosphatase, low molecular weight.
    
 0.618
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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