STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEM77666.1Sugar-phosphate isomerase, RpiB/LacA/LacB family; TIGRFAM: Ribose/galactose isomerase; Ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; Protein-tyrosine phosphatase, low molecular weight; KEGG: tit:Thit_0129 sugar-phosphate isomerase, RpiB/LacA/LacB family; SMART: Protein-tyrosine phosphatase, low molecular weight. (302 aa)    
Predicted Functional Partners:
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
    
 0.941
AEM78873.1
Manually curated; PFAM: Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family.
 
 
 0.940
AEM79295.1
6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
    
 0.940
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
  
 0.924
AEM78289.1
PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domain III; Alpha-D-phosphohexomutase, C-terminal; KEGG: tbo:Thebr_1593 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II.
  
 
 0.916
AEM79998.1
PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; KEGG: tte:TTE2704 phosphomannomutase.
  
 
 0.916
AEM78524.1
KEGG: thx:Thet_1486 6-phosphogluconate dehydrogenase, decarboxylating; TIGRFAM: 6-phosphogluconate dehydrogenase related protein; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; 6-phosphogluconate dehydrogenase, C-terminal.
    
 0.912
AEM77805.1
Transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: thx:Thet_1947 transketolase central region.
  
 
 0.910
AEM79132.1
Transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: thx:Thet_1012 transketolase domain-containing protein.
  
 
 0.910
AEM79426.1
Transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: thx:Thet_1947 transketolase central region.
  
 
 0.910
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.