Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEM77925.1PFAM: Cobalamin (vitamin B12) biosynthesis CbiX; KEGG: tit:Thit_0350 cobalamin (vitamin B12) biosynthesis CbiX protein. (105 aa)    
Predicted Functional Partners:
hemL
TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: thx:Thet_0364 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III.
 
  
 0.879
AEM77930.1
TIGRFAM: Sirohaem synthase, N-terminal; KEGG: tmt:Tmath_0434 siroheme synthase.
  
  
 0.864
cobS
Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
   
 0.830
AEM77928.1
KEGG: tmt:Tmath_0432 uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase.
  
  
 0.822
AEM77923.1
Cobalbumin biosynthesis protein; PFAM: Cobinamide kinase/cobinamide phosphate guanyltransferase; KEGG: thx:Thet_0348 adenosylcobinamide-phosphate guanylyltransferase.
     
 0.787
AEM77922.1
KEGG: tbo:Thebr_1944 L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase, class I/II.
     
 0.713
AEM77921.1
KEGG: thx:Thet_1007 hypothetical protein.
       0.643
AEM77920.1
KEGG: thx:Thet_1006 hypothetical protein.
       0.625
cbiA
Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
   
 0.582
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.561
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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