Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEM77930.1TIGRFAM: Sirohaem synthase, N-terminal; KEGG: tmt:Tmath_0434 siroheme synthase. (190 aa)    
Predicted Functional Partners:
AEM77928.1
KEGG: tmt:Tmath_0432 uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase.
 
 0.999
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.990
AEM77929.1
Delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; KEGG: tmt:Tmath_0433 porphobilinogen synthase; Belongs to the ALAD family.
 
  
 0.977
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 
 0.945
hemL
TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: thx:Thet_0364 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III.
   
 0.887
AEM77925.1
PFAM: Cobalamin (vitamin B12) biosynthesis CbiX; KEGG: tit:Thit_0350 cobalamin (vitamin B12) biosynthesis CbiX protein.
  
  
 0.864
cbiA
Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.692
AEM79467.1
KEGG: dtu:Dtur_0731 uroporphyrinogen decarboxylase (URO-D); manually curated; PFAM: Uroporphyrinogen decarboxylase (URO-D); Belongs to the uroporphyrinogen decarboxylase family.
  
  
 0.639
polA
5'-3' exonuclease, resolvase-like domain-containing protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.638
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
  
 0.637
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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