Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AEM78024.1KEGG: tbo:Thebr_1827 hypothetical protein. (188 aa)    
Predicted Functional Partners:
AEM78021.1
Hypothetical protein; Manually curated; KEGG: tbo:Thebr_1830 FlgN family protein.
 
  
 0.955
AEM78019.1
TIGRFAM: flagellar operon protein TIGR03826; KEGG: tbo:Thebr_1832 flagellar operon protein YvyF.
 
  
 0.912
AEM78023.1
KEGG: tbo:Thebr_1828 flagellar hook-associated protein 3; TIGRFAM: Flagellar hook-associated protein 3; PFAM: Flagellin, N-terminal; Flagellin, C-terminal.
 
  
 0.910
fliW
Flagellar assembly factor fliW; Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
 
  
 0.905
flgK
KEGG: tbo:Thebr_1829 flagellar hook-associated protein FlgK; TIGRFAM: Flagellar hook-associated protein, FlgK; PFAM: Protein of unknown function DUF1078, C-terminal; Flagellar basal body rod protein, N-terminal.
 
  
 0.877
csrA
Carbon storage regulator, CsrA; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
  
    0.851
AEM78020.1
PFAM: Anti-sigma-28 factor, FlgM; KEGG: tbo:Thebr_1831 anti-sigma-28 factor FlgM family protein.
  
  
 0.828
AEM78348.1
KEGG: thx:Thet_0753 hypothetical protein.
  
     0.673
AEM77615.1
PFAM: Protein of unknown function DUF327; KEGG: tbo:Thebr_2195 hypothetical protein.
 
     0.663
AEM78018.1
PFAM: Phosphoribosyltransferase; KEGG: tbo:Thebr_1833 phosphoribosyltransferase.
     
 0.584
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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