Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEM78745.1 | glyA | Thewi_1322 | Thewi_2026 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.813 |
| AEM78745.1 | guaB | Thewi_1322 | Thewi_0666 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.905 |
| AEM78745.1 | purC | Thewi_1322 | Thewi_0670 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: tmt:Tmath_0630 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.997 |
| AEM78745.1 | purD | Thewi_1322 | Thewi_0678 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: tbo:Thebr_1748 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | 0.956 |
| AEM78745.1 | purE | Thewi_1322 | Thewi_0669 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.951 |
| AEM78745.1 | purF | Thewi_1322 | Thewi_0674 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.971 |
| AEM78745.1 | purH | Thewi_1322 | Thewi_0677 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: thx:Thet_0578 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; HAMAP: Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like. | 0.995 |
| AEM78745.1 | purM | Thewi_1322 | Thewi_0675 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | KEGG: tmt:Tmath_0635 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. | 0.925 |
| AEM78745.1 | purN | Thewi_1322 | Thewi_0676 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.899 |
| AEM78745.1 | purQ | Thewi_1322 | Thewi_0672 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.883 |
| glyA | AEM78745.1 | Thewi_2026 | Thewi_1322 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | 0.813 |
| glyA | guaB | Thewi_2026 | Thewi_0666 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.745 |
| glyA | purC | Thewi_2026 | Thewi_0670 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: tmt:Tmath_0630 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.786 |
| glyA | purD | Thewi_2026 | Thewi_0678 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: tbo:Thebr_1748 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | 0.863 |
| glyA | purF | Thewi_2026 | Thewi_0674 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.804 |
| glyA | purH | Thewi_2026 | Thewi_0677 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: thx:Thet_0578 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; HAMAP: Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like. | 0.994 |
| glyA | purM | Thewi_2026 | Thewi_0675 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: tmt:Tmath_0635 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. | 0.662 |
| glyA | purN | Thewi_2026 | Thewi_0676 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.970 |
| glyA | purQ | Thewi_2026 | Thewi_0672 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.510 |
| guaB | AEM78745.1 | Thewi_0666 | Thewi_1322 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | 0.905 |
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