STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (213 aa)    
Predicted Functional Partners:
AEM78173.1
KEGG: tit:Thit_0600 phosphomethylpyrimidine kinase; TIGRFAM: Phosphomethylpyrimidine kinase type-2; PFAM: Phosphomethylpyrimidine kinase type-1.
 
 0.999
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
 
 0.999
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.931
rsgA
Ribosome biogenesis GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.908
AEM78176.1
KEGG: thx:Thet_0625 ThiW protein; TIGRFAM: ThiW; PFAM: ThiW.
 
     0.884
AEM78136.1
KEGG: tbo:Thebr_1743 biotin and thiamin synthesis associated; PFAM: Biotin/thiamin synthesis-associated protein; Radical SAM; SMART: Elongator protein 3/MiaB/NifB.
  
  
 0.876
AEM78177.1
KEGG: thx:Thet_0626 hydroxymethylpyrimidine transporter CytX; TIGRFAM: Hydroxymethylpyrimidine transporter CytX; PFAM: Permease, cytosine/purines, uracil, thiamine, allantoin.
 
  
 0.849
AEM79807.1
PFAM: ThiamineS; KEGG: tte:TTE2469 hypothetical protein.
  
  
 0.812
AEM79809.1
KEGG: tte:TTE2471 thiamine biosynthesis protein ThiF; TIGRFAM: Thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding fold.
     0.710
AEM77868.1
PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; KEGG: tbo:Thebr_0875 UBA/ThiF-type NAD/FAD-binding protein.
  
  
 0.708
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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