STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larCProtein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (389 aa)    
Predicted Functional Partners:
AEM78308.1
Hypothetical protein; Manually curated; KEGG: tbo:Thebr_1576 PP-loop domain-containing protein.
  
 0.985
AEM78309.1
PFAM: 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: thx:Thet_0715 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase.
 
  
 0.984
AEM77748.1
PFAM: Cobalamin (vitamin B12) biosynthesis CbiM; KEGG: thx:Thet_0230 cobalamin (vitamin B12) biosynthesis CbiM protein.
 
    0.550
AEM78307.1
Methyl-accepting chemotaxis sensory transducer with Cache sensor; KEGG: tte:TTE0759 methyl-accepting chemotaxis protein; PFAM: Chemotaxis methyl-accepting receptor, signalling; Cache; HAMP linker domain; SMART: Chemotaxis methyl-accepting receptor, signalling; HAMP linker domain.
       0.502
AEM77691.1
PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: thx:Thet_0151 4Fe-4S ferredoxin iron-sulfur-binding domain-containing protein.
 
    0.442
AEM78306.1
KEGG: thx:Thet_0713 CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
       0.407
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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