STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEM78366.1Signal peptide peptidase SppA, 36K type; KEGG: tte:TTE0850 periplasmic serine protease (ClpP class); TIGRFAM: Peptidase S49, SppA; PFAM: Peptidase S49. (304 aa)    
Predicted Functional Partners:
AEM78364.1
ABC transporter related protein; KEGG: tte:TTE0848 ABC-type multidrug transport system, ATPase component; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core.
  
    0.767
AEM78365.1
Hypothetical protein; Manually curated; KEGG: tte:TTE0849 hypothetical protein.
       0.742
AEM78367.1
PFAM: Nucleotidyltransferase; KEGG: tmt:Tmath_0834 DNA polymerase beta domain protein region.
       0.671
AEM78368.1
PFAM: Protein of unknown function DUF86; KEGG: tbo:Thebr_1517 hypothetical protein.
       0.671
AEM78304.1
PFAM: Protein of unknown function DUF2143; KEGG: tit:Thit_0724 protein of unknown function DUF2143.
 
     0.571
AEM78369.1
KEGG: tte:TTE0851 hypothetical protein.
       0.554
AEM78363.1
KEGG: tbo:Thebr_1521 hypothetical protein.
       0.509
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.412
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.