STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEM78437.1Metal dependent phosphohydrolase; TIGRFAM: Conserved hypothetical protein CHP00488; HDIG; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; KEGG: tit:Thit_0857 metal dependent phosphohydrolase; SMART: Metal-dependent phosphohydrolase, HD region. (194 aa)    
Predicted Functional Partners:
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
  
 0.996
rsfS
Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
  
    0.952
AEM78438.1
KEGG: tmt:Tmath_0900 cell envelope-related transcriptional attenuator; TIGRFAM: Cell envelope-related transcriptional attenuator; PFAM: Cell envelope-related transcriptional attenuator.
 
    0.848
polC
DNA polymerase III polC-type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
     0.630
obg
GTP1/OBG sub domain protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  
    0.627
AEM78430.1
KEGG: tpd:Teth39_1436 hypothetical protein.
  
    0.609
AEM78432.1
PFAM: Protein of unknown function DUF464; KEGG: tbo:Thebr_1469 hypothetical protein.
 
    0.598
AEM78440.1
PFAM: YheO-like; KEGG: tbo:Thebr_1461 YheO-like domain-containing protein.
       0.551
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
    0.548
AEM78632.1
KEGG: tbo:Thebr_1092 HAD superfamily (subfamily IIIA) phosphatase; TIGRFAM: HAD-superfamily phosphatase, subfamily IIIA; HAD-superfamily hydrolase, subfamily IIIA; PFAM: Haloacid dehalogenase-like hydrolase.
 
  
 0.533
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.