Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pcpPyrrolidone-carboxylate peptidase; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family. (205 aa)    
Predicted Functional Partners:
AEM78499.1
PFAM: Protein of unknown function DUF979; KEGG: thx:Thet_1530 hypothetical protein.
 
    0.948
AEM78498.1
PFAM: Protein of unknown function DUF969; KEGG: thx:Thet_1531 hypothetical protein.
 
     0.932
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
   
   0.744
AEM78744.1
TIGRFAM: Sporulation stage V, protein K; PFAM: ATPase, AAA-type, core; KEGG: tbo:Thebr_1211 stage V sporulation protein K; SMART: ATPase, AAA+ type, core.
    
   0.740
AEM79378.1
KEGG: tbo:Thebr_0550 MIP family channel protein; TIGRFAM: Aquaporin; PFAM: Major intrinsic protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.
    
 
 0.740
AEM79154.1
KEGG: thx:Thet_1694 hypothetical protein.
    
   0.730
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
   0.725
AEM79826.1
PFAM: Copper amine oxidase-like, N-terminal; KEGG: slp:Slip_1153 copper amine oxidase domain protein.
   
 
 0.719
AEM77826.1
KEGG: thx:Thet_0285 hypothetical protein.
   
   0.692
AEM78019.1
TIGRFAM: flagellar operon protein TIGR03826; KEGG: tbo:Thebr_1832 flagellar operon protein YvyF.
   
   0.682
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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