| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEM77518.1 | AEM78827.1 | Thewi_0002 | Thewi_1405 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: tbo:Thebr_1294 DNA protecting protein DprA; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A. | 0.473 |
| AEM77518.1 | dinB | Thewi_0002 | Thewi_0251 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.951 |
| AEM77518.1 | polA | Thewi_0002 | Thewi_0961 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 5'-3' exonuclease, resolvase-like domain-containing protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.995 |
| AEM77518.1 | rnhB | Thewi_0002 | Thewi_1406 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease HII/HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.871 |
| AEM77518.1 | rpoC | Thewi_0002 | Thewi_2262 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.516 |
| AEM77518.1 | topA | Thewi_0002 | Thewi_1404 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.593 |
| AEM78408.1 | dnaJ | Thewi_0979 | Thewi_1044 | PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Sucraseferredoxin-like; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: tbo:Thebr_1492 NADH dehydrogenase (quinone). | Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.973 |
| AEM78408.1 | polA | Thewi_0979 | Thewi_0961 | PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Sucraseferredoxin-like; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: tbo:Thebr_1492 NADH dehydrogenase (quinone). | 5'-3' exonuclease, resolvase-like domain-containing protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.522 |
| AEM78408.1 | rnhB | Thewi_0979 | Thewi_1406 | PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Sucraseferredoxin-like; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: tbo:Thebr_1492 NADH dehydrogenase (quinone). | Ribonuclease HII/HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.791 |
| AEM78408.1 | topA | Thewi_0979 | Thewi_1404 | PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Sucraseferredoxin-like; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: tbo:Thebr_1492 NADH dehydrogenase (quinone). | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.481 |
| AEM78827.1 | AEM77518.1 | Thewi_1405 | Thewi_0002 | KEGG: tbo:Thebr_1294 DNA protecting protein DprA; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.473 |
| AEM78827.1 | AEM78829.1 | Thewi_1405 | Thewi_1407 | KEGG: tbo:Thebr_1294 DNA protecting protein DprA; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A. | UPF0102 protein yraN; TIGRFAM: Uncharacterised protein family UPF0102; HAMAP: Uncharacterised protein family UPF0102; KEGG: tbo:Thebr_1296 hypothetical protein; PFAM: Uncharacterised protein family UPF0102; Belongs to the UPF0102 family. | 0.848 |
| AEM78827.1 | rnhB | Thewi_1405 | Thewi_1406 | KEGG: tbo:Thebr_1294 DNA protecting protein DprA; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A. | Ribonuclease HII/HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.719 |
| AEM78827.1 | topA | Thewi_1405 | Thewi_1404 | KEGG: tbo:Thebr_1294 DNA protecting protein DprA; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.910 |
| AEM78829.1 | AEM78827.1 | Thewi_1407 | Thewi_1405 | UPF0102 protein yraN; TIGRFAM: Uncharacterised protein family UPF0102; HAMAP: Uncharacterised protein family UPF0102; KEGG: tbo:Thebr_1296 hypothetical protein; PFAM: Uncharacterised protein family UPF0102; Belongs to the UPF0102 family. | KEGG: tbo:Thebr_1294 DNA protecting protein DprA; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A. | 0.848 |
| AEM78829.1 | rnhB | Thewi_1407 | Thewi_1406 | UPF0102 protein yraN; TIGRFAM: Uncharacterised protein family UPF0102; HAMAP: Uncharacterised protein family UPF0102; KEGG: tbo:Thebr_1296 hypothetical protein; PFAM: Uncharacterised protein family UPF0102; Belongs to the UPF0102 family. | Ribonuclease HII/HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.839 |
| AEM78829.1 | topA | Thewi_1407 | Thewi_1404 | UPF0102 protein yraN; TIGRFAM: Uncharacterised protein family UPF0102; HAMAP: Uncharacterised protein family UPF0102; KEGG: tbo:Thebr_1296 hypothetical protein; PFAM: Uncharacterised protein family UPF0102; Belongs to the UPF0102 family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.646 |
| dinB | AEM77518.1 | Thewi_0251 | Thewi_0002 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.951 |
| dinB | polA | Thewi_0251 | Thewi_0961 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 5'-3' exonuclease, resolvase-like domain-containing protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.766 |
| dinB | rnhB | Thewi_0251 | Thewi_1406 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Ribonuclease HII/HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.714 |
