Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa)    
Predicted Functional Partners:
AEM78887.1
UPF0296 protein; KEGG: tbo:Thebr_1354 hypothetical protein; HAMAP: UPF0296 protein; PFAM: Protein of unknown function DUF370; Belongs to the RemA family.
  
    0.973
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.962
AEM79683.1
KEGG: tbo:Thebr_0309 hypoxanthine phosphoribosyltransferase; TIGRFAM: Hypoxanthine phosphoribosyl transferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.947
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
  
 0.943
AEM78594.1
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.928
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.925
AEM78745.1
KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase.
   
 0.925
AEM78888.1
KEGG: tbo:Thebr_1355 YicC-like domain-containing protein; TIGRFAM: Conserved hypothetical protein CHP00255; PFAM: YicC-like, N-terminal; Domain of unknown function DUF1732.
  
    0.917
AEM77883.1
KEGG: tbo:Thebr_1985 5'-nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SH3, type 3; SMART: Bacterial SH3-like region.
    
  0.906
AEM79650.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
     
 0.904
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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