STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEM78932.1KEGG: tbo:Thebr_0920 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA. (265 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
 
 0.979
pheA
PFAM: Prephenate dehydratase; Amino acid-binding ACT; KEGG: tbo:Thebr_1009 prephenate dehydratase.
 
  
 0.912
AEM78533.1
KEGG: thx:Thet_1477 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA.
  
  
 
0.902
trpE
Anthranilate synthase component I domain protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate an [...]
     
 0.818
trpC
PFAM: Indole-3-glycerol phosphate synthase; KEGG: tmt:Tmath_1420 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family.
  
  
 0.816
AEM78938.1
KEGG: tit:Thit_1429 glutamine amidotransferase of anthranilate synthase; TIGRFAM: Glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal.
  
  
 0.816
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
 0.814
trpF
PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: thx:Thet_1071 phosphoribosylanthranilate isomerase; Belongs to the TrpF family.
  
    0.809
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
  
    0.809
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
       0.800
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.