STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (391 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpF
PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: thx:Thet_1071 phosphoribosylanthranilate isomerase; Belongs to the TrpF family.
  
 0.999
trpC
PFAM: Indole-3-glycerol phosphate synthase; KEGG: tmt:Tmath_1420 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.998
AEM78938.1
KEGG: tit:Thit_1429 glutamine amidotransferase of anthranilate synthase; TIGRFAM: Glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal.
 
  
 0.995
trpE
Anthranilate synthase component I domain protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate an [...]
 
  
 0.995
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.923
AEM78724.1
PFAM: Phosphoglycerate mutase; KEGG: tbo:Thebr_1192 phosphoglycerate mutase.
    
  0.901
AEM78528.1
KEGG: tbo:Thebr_1005 L-serine dehydratase, iron-sulfur-dependent subunit beta; TIGRFAM: Iron-sulphur-dependent L-serine dehydratase beta subunit; PFAM: Serine dehydratase beta chain; Amino acid-binding ACT.
     
  0.900
AEM78529.1
KEGG: tbo:Thebr_1006 L-serine dehydratase, iron-sulfur-dependent subunit alpha; TIGRFAM: L-serine dehydratase, alpha subunit; PFAM: Serine dehydratase alpha chain.
     
  0.900
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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