Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEM79070.1Nitrogen-fixing NifU domain-containing protein; PFAM: NIF system FeS cluster assembly, NifU, C-terminal; KEGG: tbo:Thebr_0775 nitrogen-fixing NifU domain-containing protein. (73 aa)    
Predicted Functional Partners:
lipA
Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
  
 0.900
AEM77965.1
KEGG: tbo:Thebr_1890 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding.
     
 0.648
AEM77911.1
KEGG: tbo:Thebr_1958 SUF system FeS assembly protein; TIGRFAM: SUF system FeS cluster assembly, SufU scaffold; PFAM: NIF system FeS cluster assembly, NifU, N-terminal.
  
 
 0.639
AEM79953.1
KEGG: tbo:Thebr_0126 SUF system FeS assembly protein; TIGRFAM: SUF system FeS cluster assembly, SufU scaffold; PFAM: NIF system FeS cluster assembly, NifU, N-terminal.
  
 
 0.639
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
  
 
 0.630
AEM79071.1
KEGG: thx:Thet_0868 putative GAF sensor protein; PFAM: GAF; SMART: GAF.
       0.626
AEM79025.1
PFAM: Aminotransferase, class V/Cysteine desulfurase; KEGG: tbo:Thebr_0819 class V aminotransferase.
 
 
 0.612
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
 
 0.609
AEM79696.1
KEGG: tmt:Tmath_2023 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
     
 0.608
AEM79068.1
KEGG: tbo:Thebr_0778 hypothetical protein.
       0.537
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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