| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEM78927.1 | AEM78941.1 | Thewi_1511 | Thewi_1526 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tmt:Tmath_1414 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tbo:Thebr_0909 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.908 |
| AEM78927.1 | AEM79158.1 | Thewi_1511 | Thewi_1765 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tmt:Tmath_1414 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | 0.977 |
| AEM78927.1 | AEM79159.1 | Thewi_1511 | Thewi_1766 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tmt:Tmath_1414 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | PFAM: Methylenetetrahydrofolate reductase; KEGG: thx:Thet_1699 methylenetetrahydrofolate reductase. | 0.643 |
| AEM78927.1 | AEM79415.1 | Thewi_1511 | Thewi_2050 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tmt:Tmath_1414 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | KEGG: thx:Thet_1939 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. | 0.928 |
| AEM78927.1 | metK | Thewi_1511 | Thewi_0557 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tmt:Tmath_1414 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.927 |
| AEM78941.1 | AEM78927.1 | Thewi_1526 | Thewi_1511 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tbo:Thebr_0909 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tmt:Tmath_1414 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.908 |
| AEM78941.1 | AEM79158.1 | Thewi_1526 | Thewi_1765 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tbo:Thebr_0909 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | 0.977 |
| AEM78941.1 | AEM79159.1 | Thewi_1526 | Thewi_1766 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tbo:Thebr_0909 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | PFAM: Methylenetetrahydrofolate reductase; KEGG: thx:Thet_1699 methylenetetrahydrofolate reductase. | 0.643 |
| AEM78941.1 | AEM79415.1 | Thewi_1526 | Thewi_2050 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tbo:Thebr_0909 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | KEGG: thx:Thet_1939 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. | 0.926 |
| AEM78941.1 | metK | Thewi_1526 | Thewi_0557 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tbo:Thebr_0909 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.927 |
| AEM79158.1 | AEM78927.1 | Thewi_1765 | Thewi_1511 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tmt:Tmath_1414 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.977 |
| AEM79158.1 | AEM78941.1 | Thewi_1765 | Thewi_1526 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tbo:Thebr_0909 Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.977 |
| AEM79158.1 | AEM79159.1 | Thewi_1765 | Thewi_1766 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | PFAM: Methylenetetrahydrofolate reductase; KEGG: thx:Thet_1699 methylenetetrahydrofolate reductase. | 0.999 |
| AEM79158.1 | AEM79415.1 | Thewi_1765 | Thewi_2050 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | KEGG: thx:Thet_1939 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. | 0.966 |
| AEM79158.1 | AEM79416.1 | Thewi_1765 | Thewi_2051 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; KEGG: tmt:Tmath_1812 homoserine dehydrogenase. | 0.946 |
| AEM79158.1 | AEM79932.1 | Thewi_1765 | Thewi_2607 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: tbo:Thebr_0146 homoserine dehydrogenase. | 0.946 |
| AEM79158.1 | fhs | Thewi_1765 | Thewi_2332 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | KEGG: thx:Thet_2122 formate--tetrahydrofolate ligase; HAMAP: Formate-tetrahydrofolate ligase, FTHFS; PFAM: Formate-tetrahydrofolate ligase, FTHFS. | 0.964 |
| AEM79158.1 | gcvT | Thewi_1765 | Thewi_0294 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.963 |
| AEM79158.1 | glyA | Thewi_1765 | Thewi_2026 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
| AEM79158.1 | metK | Thewi_1765 | Thewi_0557 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.965 |
