STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEM79180.1TIGRFAM: DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: tbo:Thebr_0699 DNA polymerase III subunit alpha; SMART: Polymerase/histidinol phosphatase, N-terminal. (1145 aa)    
Predicted Functional Partners:
AEM77518.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.992
AEM78459.1
KEGG: thx:Thet_0844 DNA polymerase III subunit delta; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta.
  
 0.991
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 0.985
AEM77616.1
TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: tbo:Thebr_2194 DNA polymerase III subunit delta'.
 
 0.984
polC
DNA polymerase III polC-type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
0.929
AEM79181.1
Putative signal transduction protein with CBS and DRTGG domains; KEGG: tbo:Thebr_0698 DRTGG domain-containing protein; PFAM: DRTGG; Cystathionine beta-synthase, core; SMART: Cystathionine beta-synthase, core.
       0.822
AEM78342.1
PFAM: Primosome PriB/single-strand DNA-binding; KEGG: thx:Thet_0747 single-strand-binding protein/primosomal replication protein N.
   
 
 0.814
AEM80018.1
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
   
 
 0.814
polA
5'-3' exonuclease, resolvase-like domain-containing protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 
 0.805
AEM79177.1
KEGG: thx:Thet_1715 pyruvate kinase; TIGRFAM: Pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; PEP-utilising enzyme, mobile region.
  
  
 0.734
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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