STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
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Cooccurrence
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[Homology]
Score
hprKHPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (gluc [...] (305 aa)    
Predicted Functional Partners:
AEM79182.1
KEGG: tbo:Thebr_0697 phosphocarrier, HPr family; TIGRFAM: Phosphotransferase system, phosphocarrier HPr protein; PFAM: Phosphotransferase system, phosphocarrier HPr protein.
 
 
 
 0.887
AEM79314.1
KEGG: thx:Thet_1853 glucokinase, ROK family; TIGRFAM: Glucokinase ROK; PFAM: ROK; ATPase, BadF/BadG/BcrA/BcrD type.
 
   
 0.824
AEM79315.1
HAMAP: hydrolase ycdX; PFAM: PHP, C-terminal; KEGG: tbo:Thebr_0592 PHP domain-containing protein; SMART: Polymerase/histidinol phosphatase, N-terminal.
       0.772
AEM79313.1
PFAM: AMP-dependent synthetase/ligase; KEGG: thx:Thet_1852 AMP-dependent synthetase and ligase.
       0.733
AEM79312.1
PFAM: Protein of unknown function DUF624; KEGG: thx:Thet_1851 hypothetical protein.
       0.683
AEM79644.1
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
   
 0.676
AEM77965.1
KEGG: tbo:Thebr_1890 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding.
   
   0.648
AEM79696.1
KEGG: tmt:Tmath_2023 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
   
   0.648
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
 
   
 0.642
AEM78875.1
KEGG: tbo:Thebr_1342 serine/threonine-protein kinase-like domain-containing protein; PFAM: Serine/threonine-protein kinase-like domain; PASTA; SMART: Serine/threonine-protein kinase domain; Tyrosine-protein kinase, subgroup, catalytic domain; PASTA.
   
 
 0.640
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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