Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEM79467.1KEGG: dtu:Dtur_0731 uroporphyrinogen decarboxylase (URO-D); manually curated; PFAM: Uroporphyrinogen decarboxylase (URO-D); Belongs to the uroporphyrinogen decarboxylase family. (326 aa)    
Predicted Functional Partners:
AEM77928.1
KEGG: tmt:Tmath_0432 uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase.
  
 
 0.963
AEM79471.1
KEGG: dsy:DSY1510 hypothetical protein; Belongs to the uroporphyrinogen decarboxylase family.
 
 
 0.962
AEM79468.1
KEGG: ate:Athe_2582 methionine synthase; TIGRFAM: Corrinoid methyltransferase, Methanosarcina species; PFAM: Cobalamin (vitamin B12)-binding; Methionine synthase, cobalamin (vitamin B12)-binding module, cap.
  
 0.925
AEM79469.1
Transcriptional regulator, AraC family; KEGG: hor:Hore_15370 helix-turn-helix-domain containing protein AraC type; PFAM: Helix-turn-helix, AraC type; Transcriptional regulator, histidine kinase sensor, N-terminal; SMART: Helix-turn-helix, AraC domain.
 
   
 0.857
AEM79466.1
KEGG: ttm:Tthe_2447 vitamin B12 dependent methionine synthase activation region; manually curated; PFAM: Vitamin B12 dependent methionine synthase, activation region; Ferredoxin.
 
  
 0.847
AEM79470.1
Hypothetical protein; Manually curated.
 
  
 0.801
AEM79158.1
PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: tbo:Thebr_0717 homocysteine S-methyltransferase.
  
  
 0.713
hemL
TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: thx:Thet_0364 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III.
 
  
 0.687
AEM78285.1
PFAM: D-Lysine 5,6-aminomutase alpha subunit; KEGG: tte:TTE0726 D-lysine 5,6-aminomutase alpha subunit.
   
 
 0.683
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 
 0.652
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.