STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEM79554.1Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (506 aa)    
Predicted Functional Partners:
AEM79553.1
PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; KEGG: tbo:Thebr_0455 MazG nucleotide pyrophosphohydrolase.
       0.754
AEM77584.1
PFAM: Beta-galactosidase trimerisation; Glycoside hydrolase, family 5; KEGG: tbo:Thebr_2228 beta-galactosidase trimerisation domain-containing protein; Belongs to the glycosyl hydrolase 5 (cellulase A) family.
  
     0.731
AEM77827.1
KEGG: thx:Thet_0286 aminopeptidase-like protein.
  
     0.705
AEM79038.1
KEGG: tbo:Thebr_0806 hypothetical protein.
  
     0.704
AEM77679.1
KEGG: tte:TTE0165 hypothetical protein; PFAM: Cell surface receptor IPT/TIG; Fibronectin, type III; SMART: Fibronectin, type III; Cell surface receptor IPT/TIG.
  
 
   0.702
AEM79266.1
Hypothetical protein; Manually curated; KEGG: tte:TTE1567 hypothetical protein.
  
     0.692
AEM79382.1
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
  
     0.682
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.672
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
    
 0.643
AEM79551.1
PFAM: Spore coat protein CotF-like; KEGG: tbo:Thebr_0457 coat F domain-containing protein.
 
     0.621
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.