STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEM79555.1Exodeoxyribonuclease III Xth; KEGG: tte:TTE2226 exonuclease III; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; PFAM: Endonuclease/exonuclease/phosphatase. (257 aa)    
Predicted Functional Partners:
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.994
polA
5'-3' exonuclease, resolvase-like domain-containing protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.952
AEM77518.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.924
AEM78103.1
KEGG: tbo:Thebr_1771 8-oxoguanine DNA glycosylase domain-containing protein; PFAM: 8-oxoguanine DNA glycosylase, N-terminal; HhH-GPD domain; SMART: HhH-GPD domain.
  
 0.888
AEM79494.1
KEGG: tbo:Thebr_0487 DNA polymerase LigD, ligase domain-containing protein; TIGRFAM: DNA polymerase LigD, ligase region; PFAM: ATP dependent DNA ligase, central.
  
 
 0.887
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
    0.871
AEM78648.1
KEGG: tbo:Thebr_1108 xylose isomerase domain-containing protein; PFAM: Xylose isomerase, TIM barrel domain; SMART: Endodeoxyribonuclease IV.
    
 
 0.832
hfq
Protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.
    
 
 0.780
AEM77579.1
TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; RNA-binding S4; KEGG: tbo:Thebr_2236 pseudouridine synthase; SMART: RNA-binding S4.
  
    0.777
AEM78709.1
TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; RNA-binding S4; KEGG: tbo:Thebr_1169 pseudouridine synthase; SMART: RNA-binding S4.
  
    0.747
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.