Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEM79709.1Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor; SMART: Signal transduction response regulator, receiver region; PAS; PAC motif; manually curated; KEGG: tit:Thit_0615 response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor; TIGRFAM: PAS; PFAM: PAS fold; Signal transduction response regulator, receiver region; Diguanylate cyclase, predicted. (676 aa)    
Predicted Functional Partners:
AEM79712.1
TIGRFAM: Diguanylate cyclase, predicted; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; KEGG: tbo:Thebr_0292 EAL domain-containing protein; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted.
 
 
0.935
AEM79649.1
Diguanylate cyclase with GAF sensor; TIGRFAM: Diguanylate cyclase, predicted; PFAM: Diguanylate cyclase, predicted; GAF; KEGG: tbo:Thebr_0340 diguanylate cyclase; SMART: Diguanylate cyclase, predicted; GAF.
 
 
0.926
AEM77568.1
Putative PAS/PAC sensor protein; TIGRFAM: PAS; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; HAMP linker domain; PAS fold; KEGG: tbo:Thebr_2247 PAS sensor protein; SMART: Metal-dependent phosphohydrolase, HD region; PAS; HAMP linker domain.
 
 0.884
AEM78162.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: Diguanylate cyclase, predicted; PAS; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold-3; PAS fold; KEGG: tte:TTE1081 diguanylate cyclase/phosphodiesterase; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS; PAC motif.
 
 
0.884
AEM78544.1
Integral membrane sensor signal transduction histidine kinase; KEGG: tbo:Thebr_0281 ATP-binding region ATPase domain-containing protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain.
 
 
 0.818
AEM79728.1
TIGRFAM: Diguanylate cyclase, predicted; PFAM: Diguanylate cyclase, predicted; Signal transduction response regulator, receiver region; KEGG: bmd:BMD_0935 response regulator diguanylate cyclase/phosphodiesterase; SMART: Diguanylate cyclase, predicted; Signal transduction response regulator, receiver region.
  
 
 0.816
AEM79565.1
TIGRFAM: HDIG; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; KEGG: tte:TTE1032 HD-GYP domain-containing protein; SMART: Metal-dependent phosphohydrolase, HD region.
   
 0.773
AEM78406.1
KEGG: thx:Thet_0794 histidine kinase; PFAM: ATP-binding region, ATPase-like; SMART: ATP-binding region, ATPase-like.
  
 
 0.771
AEM79800.1
Integral membrane sensor signal transduction histidine kinase; KEGG: ctc:CTC01951 alkaline phosphatase synthesis sensor protein PhoR; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain.
  
 
 0.771
AEM79900.1
Integral membrane sensor signal transduction histidine kinase; KEGG: tbo:Thebr_0171 ATP-binding region ATPase domain-containing protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain.
 
 0.673
Your Current Organism:
Thermoanaerobacter wiegelii
NCBI taxonomy Id: 697303
Other names: T. wiegelii Rt8.B1, Thermoanaerobacter wiegelii Rt8.B1, Thermoanaerobacter wiegelii str. Rt8.B1, Thermoanaerobacter wiegelii strain Rt8.B1
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