| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEM78745.1 | AEM79905.1 | Thewi_1322 | Thewi_2580 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | 0.677 |
| AEM78745.1 | guaA | Thewi_1322 | Thewi_0667 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.879 |
| AEM78745.1 | prs | Thewi_1322 | Thewi_2577 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.619 |
| AEM78745.1 | purA | Thewi_1322 | Thewi_2668 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.998 |
| AEM78745.1 | purF | Thewi_1322 | Thewi_0674 | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.993 |
| AEM79892.1 | AEM79905.1 | Thewi_2567 | Thewi_2580 | PFAM: Protein of unknown function DUF1021; KEGG: tbo:Thebr_0180 hypothetical protein. | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | 0.664 |
| AEM79905.1 | AEM78745.1 | Thewi_2580 | Thewi_1322 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | KEGG: tbo:Thebr_1212 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. | 0.677 |
| AEM79905.1 | AEM79892.1 | Thewi_2580 | Thewi_2567 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | PFAM: Protein of unknown function DUF1021; KEGG: tbo:Thebr_0180 hypothetical protein. | 0.664 |
| AEM79905.1 | codY | Thewi_2580 | Thewi_1401 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.594 |
| AEM79905.1 | glmU | Thewi_2580 | Thewi_2578 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.697 |
| AEM79905.1 | guaA | Thewi_2580 | Thewi_0667 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.802 |
| AEM79905.1 | murC | Thewi_2580 | Thewi_2581 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.682 |
| AEM79905.1 | prs | Thewi_2580 | Thewi_2577 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.633 |
| AEM79905.1 | purA | Thewi_2580 | Thewi_2668 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.795 |
| AEM79905.1 | purF | Thewi_2580 | Thewi_0674 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.542 |
| AEM79905.1 | spoVG | Thewi_2580 | Thewi_2579 | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | Septation protein spoVG; Could be involved in septation. | 0.675 |
| codY | AEM79905.1 | Thewi_1401 | Thewi_2580 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | 0.594 |
| codY | guaA | Thewi_1401 | Thewi_0667 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.451 |
| glmU | AEM79905.1 | Thewi_2578 | Thewi_2580 | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Purine operon repressor, PurR; KEGG: tbo:Thebr_0165 pur operon repressor; TIGRFAM: Pur operon repressor; PFAM: Bacterial purine repressor, N-terminal; Phosphoribosyltransferase. | 0.697 |
| glmU | murC | Thewi_2578 | Thewi_2581 | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.840 |
