G7K_3095-t1 protein (Saitoella complicata) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:

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[Homology]

Score

G7K_3095-t1

NMO domain-containing protein. (361 aa)

Predicted Functional Partners:

G7K_0307-t1

0.804

G7K_4202-t1

0.663

G7K_4046-t1

0.663

G7K_4709-t1

0.660

G7K_0328-t1

0.659

G7K_1639-t1

0.658

G7K_6456-t1

0.653

G7K_0353-t1

0.651

G7K_2424-t1

0.651

G7K_5669-t1

0.651

Your Current Organism:

Saitoella complicata

NCBI taxonomy Id: 698492
Other names: S. complicata NRRL Y-17804, Saitoella complicata CBS 7301, Saitoella complicata CCRC 22490, Saitoella complicata IAM 12963, Saitoella complicata JCM 7358, Saitoella complicata NBRC 10748, Saitoella complicata NRRL Y-17804

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G7K_0307-t1	G7K_3095-t1	A0A0E9N8B0	A0A0E9NGK5	Uncharacterized protein.	NMO domain-containing protein.	0.804
G7K_0328-t1	G7K_0353-t1	A0A0E9N9J7	A0A0E9N8I7	Ribosomal_S10 domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.999
G7K_0328-t1	G7K_1639-t1	A0A0E9N9J7	A0A0E9NCL0	Ribosomal_S10 domain-containing protein.	Elp3 domain-containing protein.	0.999
G7K_0328-t1	G7K_3095-t1	A0A0E9N9J7	A0A0E9NGK5	Ribosomal_S10 domain-containing protein.	NMO domain-containing protein.	0.659
G7K_0328-t1	G7K_4202-t1	A0A0E9N9J7	A0A0E9NJL1	Ribosomal_S10 domain-containing protein.	Uncharacterized protein.	0.999
G7K_0328-t1	G7K_4709-t1	A0A0E9N9J7	A0A0E9NMD9	Ribosomal_S10 domain-containing protein.	Uncharacterized protein.	0.999
G7K_0328-t1	G7K_5669-t1	A0A0E9N9J7	A0A0E9NQ70	Ribosomal_S10 domain-containing protein.	Uncharacterized protein.	0.999
G7K_0328-t1	G7K_6456-t1	A0A0E9N9J7	A0A0E9NRH2	Ribosomal_S10 domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS2 family.	0.999
G7K_0353-t1	G7K_0328-t1	A0A0E9N8I7	A0A0E9N9J7	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Ribosomal_S10 domain-containing protein.	0.999
G7K_0353-t1	G7K_1639-t1	A0A0E9N8I7	A0A0E9NCL0	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Elp3 domain-containing protein.	0.999
G7K_0353-t1	G7K_3095-t1	A0A0E9N8I7	A0A0E9NGK5	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	NMO domain-containing protein.	0.651
G7K_0353-t1	G7K_4202-t1	A0A0E9N8I7	A0A0E9NJL1	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein.	0.999
G7K_0353-t1	G7K_4709-t1	A0A0E9N8I7	A0A0E9NMD9	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein.	0.999
G7K_0353-t1	G7K_5669-t1	A0A0E9N8I7	A0A0E9NQ70	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein.	0.999
G7K_0353-t1	G7K_6456-t1	A0A0E9N8I7	A0A0E9NRH2	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein; Belongs to the universal ribosomal protein uS2 family.	0.999
G7K_1639-t1	G7K_0328-t1	A0A0E9NCL0	A0A0E9N9J7	Elp3 domain-containing protein.	Ribosomal_S10 domain-containing protein.	0.999
G7K_1639-t1	G7K_0353-t1	A0A0E9NCL0	A0A0E9N8I7	Elp3 domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.999
G7K_1639-t1	G7K_3095-t1	A0A0E9NCL0	A0A0E9NGK5	Elp3 domain-containing protein.	NMO domain-containing protein.	0.658
G7K_1639-t1	G7K_4202-t1	A0A0E9NCL0	A0A0E9NJL1	Elp3 domain-containing protein.	Uncharacterized protein.	0.999
G7K_1639-t1	G7K_4709-t1	A0A0E9NCL0	A0A0E9NMD9	Elp3 domain-containing protein.	Uncharacterized protein.	0.999

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.915

expected number of edges:

19

PPI enrichment p-value:

1.05e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098662

Inorganic cation transmembrane transport

10 of 176

1.78

4.33

3.20e-14

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

3 of 3

3.02

3.29

1.01e-06

GO:0006810

Transport

11 of 1358

0.93

1.1

6.24e-09

GO:0030003

Cellular cation homeostasis

3 of 97

1.51

1.03

0.0053

GO:0098771

Inorganic ion homeostasis

3 of 109

1.46

0.97

0.0068

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

7 of 12

2.79

7.44

4.47e-15

GO:0015078

Proton transmembrane transporter activity

8 of 86

1.99

4.87

4.78e-13

GO:0019829

ATPase-coupled cation transmembrane transporter activity

7 of 63

2.07

4.69

1.05e-11

GO:0022890

Inorganic cation transmembrane transporter activity

10 of 193

1.74

4.23

1.18e-14

GO:0009678

Pyrophosphate hydrolysis-driven proton transmembrane transporter activity

5 of 44

2.08

3.45

3.56e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033178

Proton-transporting two-sector ATPase complex, catalytic domain

6 of 17

2.57

5.58

1.11e-11

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

6 of 17

2.57

5.58

1.11e-11

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

5 of 8

2.82

5.45

5.51e-11

GO:0016469

Proton-transporting two-sector ATPase complex

7 of 55

2.13

4.82

1.11e-11

GO:0005754

Mitochondrial proton-transporting ATP synthase, catalytic core

4 of 5

2.93

4.43

6.39e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8347

Proton-transporting ATP synthase complex

6 of 14

2.65

5.72

8.65e-12

CL:8333

Proton-transporting two-sector ATPase complex

7 of 59

2.1

4.63

2.47e-11

CL:8352

Proton channel activity

3 of 5

2.8

2.76

8.32e-06

CL:13508

Copper ion transport

2 of 6

2.55

1.3

0.0042

CL:13238

Mixed, incl. Cation homeostasis, and Lipid transport

4 of 174

1.38

1.04

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 143

1.77

3.77

1.58e-11

map04016

MAPK signaling pathway - plant

2 of 7

2.48

1.45

0.0021

map01100

Metabolic pathways

8 of 2025

0.62

0.46

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-936837

Ion transport by P-type ATPases

3 of 29

2.04

1.31

0.0030

MAP-983712

Ion channel transport

3 of 62

1.71

0.94

0.0128

MAP-1852241

Organelle biogenesis and maintenance

3 of 68

1.67

0.93

0.0128

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

3 of 75

1.62

0.92

0.0128

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

6 of 13

2.69

5.93

3.63e-12

GOCC:0016020

Membrane

11 of 1420

0.91

1.05

1.91e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0139

CF(1)

5 of 6

2.94

5.66

2.89e-11

KW-0066

ATP synthesis

5 of 6

2.94

5.66

2.89e-11

KW-0375

Hydrogen ion transport

3 of 22

2.16

2.12

6.86e-05

KW-0067

ATP-binding

8 of 418

1.3

1.88

3.68e-08

KW-1278

Translocase

2 of 26

1.91

1.02

0.0104

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02874

ATP synthase alpha/beta family, beta-barrel domain

5 of 7

2.88

5.14

2.50e-10

PF00122

E1-E2 ATPase

4 of 28

2.18

2.53

9.30e-06

PF00702

Haloacid dehalogenase-like hydrolase

3 of 14

2.35

1.99

0.00017

PF00006

ATP synthase alpha/beta family, nucleotide-binding domain

2 of 4

2.72

1.34

0.0037

PF00403

Heavy-metal-associated domain

2 of 6

2.55

1.24

0.0055

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036121

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily

5 of 6

2.94

5.06

4.16e-10

IPR020003

ATPase, alpha/beta subunit, nucleotide-binding domain, active site

5 of 7

2.88

5.03

4.16e-10

IPR004100

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain

5 of 7

2.88

5.03

4.16e-10

IPR000194

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain

5 of 7

2.88

5.03

4.16e-10

IPR005722

ATP synthase, F1 complex, beta subunit

3 of 3

3.02

2.78

8.67e-06

(more ...)

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