STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
nnrDNAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of bot [...] (530 aa)    
Predicted Functional Partners:
SMB98546.1
ADP-ribose pyrophosphatase; InterPro IPR000086:IPR020084; KEGG: mta:Moth_1504 NUDIX hydrolase; SPTR: NUDIX hydrolase; PFAM: NUDIX hydrolase.
  
 0.995
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
   0.894
SMB91049.1
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE; InterPro IPR003442; COGs: COG0802 ATPase or kinase; KEGG: mta:Moth_2160 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised protein family UPF0079, ATPase.
 
 
 0.883
nuoD
NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family.
  
 
 0.810
SMB91999.1
Dihydroorotate dehydrogenase (fumarate); InterProIPR017900:IPR001295:IPR012135:IPR017896:IPR 005720; COGs: COG0167 Dihydroorotate dehydrogenase; KEGG: cdl:CDR20291_1984 dihydroorotate dehydrogenase, catalytic subunit; SPTR: Dihydroorotate dehydrogenase, catalytic subunit; PFAM: dihydroorotate oxidase; TIGRFAM: dihydroorotate dehydrogenase family protein.
  
   0.784
SMB98873.1
4Fe-4S dicluster domain-containing protein; InterPro IPR017896:IPR017900; KEGG: dae:Dtox_1356 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Putative uncharacterized protein.
  
  
 0.763
SMB98875.1
NAD(P)H-flavin reductase; InterProIPR017927:IPR012165:IPR008333:IPR001433:IPR 019480:IPR001221; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; KEGG: rmr:Rmar_2588 oxidoreductase FAD/NAD(P)-binding domain protein; SPTR: Oxidoreductase FAD/NAD(P)-binding domain protein; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain.
  
  
 0.763
SMB88567.1
23S rRNA (guanosine2251-2'-O)-methyltransferase; InterPro IPR004441:IPR013123:IPR001537; COGs: COG0566 rRNA methylase; KEGG: mta:Moth_2481 RNA methyltransferase TrmH, group 3; SPTR: RNA methyltransferase TrmH, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; TIGRFAM: RNA methyltransferase, TrmH family, group 3; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
   
 
 0.757
SMB98964.1
RNA methyltransferase, TrmH family; InterPro IPR013123:IPR001537; COGs: COG0566 rRNA methylase; KEGG: mta:Moth_1753 tRNA/rRNA methyltransferase (SpoU); SPTR: tRNA/rRNA methyltransferase (SpoU); PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
   
 
 0.757
SMB91012.1
KEGG: mta:Moth_2166 CopG family transcriptional regulator; SPTR: Transcriptional regulator, CopG family.
       0.753
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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