STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (214 aa)    
Predicted Functional Partners:
SMB94455.1
InterPro IPR004399:IPR013749; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; KEGG: mta:Moth_0867 phosphomethylpyrimidine kinase; SPTR: Phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; TIGRFAM: phosphomethylpyrimidine kinase.
 
 0.999
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
 
 0.999
SMB92781.1
Sulfur carrier protein; InterPro IPR003749:IPR010035; KEGG: mmr:Mmar10_1268 thiamine biosynthesis protein ThiS; SPTR: Thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; TIGRFAM: thiamine biosynthesis protein ThiS.
  
 
 0.998
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
 
 0.980
thiL
Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
  
 0.967
SMB95119.1
Hydroxymethylpyrimidine synthase; InterPro IPR002817; COGs: COG0422 Thiamine biosynthesis protein ThiC; KEGG: thiamine biosynthesis protein ThiC; SPTR: Phosphomethylpyrimidine synthase 2; PFAM: thiamine biosynthesis protein ThiC; TIGRFAM: thiamine biosynthesis protein ThiC.
 
 
 0.962
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.959
SMB95117.1
Hydroxymethylpyrimidine synthase; InterPro IPR002817; COGs: COG0422 Thiamine biosynthesis protein ThiC; KEGG: thiamine biosynthesis protein ThiC; SPTR: Phosphomethylpyrimidine synthase 3; PFAM: thiamine biosynthesis protein ThiC; TIGRFAM: thiamine biosynthesis protein ThiC.
 
 
 0.937
rsgA
Ribosome biogenesis GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.864
SMB98114.1
Adenylyltransferase and sulfurtransferase; InterPro IPR000594:IPR007901; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; KEGG: mta:Moth_1970 UBA/ThiF-type NAD/FAD binding fold; SPTR: UBA/THIF-type NAD/FAD binding fold; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein.
  
 
 0.857
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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