STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tsaDO-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (336 aa)    
Predicted Functional Partners:
SMB91049.1
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE; InterPro IPR003442; COGs: COG0802 ATPase or kinase; KEGG: mta:Moth_2160 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised protein family UPF0079, ATPase.
 
 0.994
SMB91055.1
tRNA threonylcarbamoyladenosine biosynthesis protein TsaB; InterPro IPR000905; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; KEGG: mta:Moth_2159 peptidase M22, glycoprotease; SPTR: Peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease.
 
 
 0.992
SMB91061.1
[SSU ribosomal protein S18P]-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.
  
 0.966
pheT
phenylalanyl-tRNA synthetase beta subunit; InterProIPR002547:IPR005121:IPR004532:IPR005146:IPR 005147; COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; KEGG: mta:Moth_1750 phenylalanyl-tRNA synthetase beta subunit; SPTR: Phenylalanyl-tRNA synthetase beta chain; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; PRIAM: Phenylalanine--tRNA ligase; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit.
 
  
 0.680
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.676
SMB91043.1
DNA polymerase; InterPro IPR005122:IPR005273; COGs: COG1573 Uracil-DNA glycosylase; KEGG: mta:Moth_2161 phage SPO1 DNA polymerase-related protein; SPTR: Phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily; TIGRFAM: phage SPO1 DNA polymerase-related protein.
       0.624
pheS
phenylalanyl-tRNA synthetase, alpha subunit; InterPro IPR006195:IPR004529:IPR004188:IPR002319; COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; KEGG: mta:Moth_1751 phenylalanyl-tRNA synthetase, alpha subunit; SPTR: Phenylalanyl-tRNA synthetase alpha chain; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
 
   
 0.620
SMB98139.1
uroporphyrinogen-III synthase; InterPro IPR000878:IPR003754:IPR003043:IPR006366; COGs: COG0007 Uroporphyrinogen-III methylase; KEGG: mta:Moth_1248 uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; SPTR: Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; TIGRFAM: uroporphyrin-III C-methyltransferase.
  
  
 0.598
gpsA
InterPro IPR011128:IPR006109:IPR006168; COGs: COG0240 Glycerol-3-phosphate dehydrogenase; KEGG: mta:Moth_1320 NAD-dependent glycerol-3-phosphate dehydrogenase-like; SPTR: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
      0.583
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.579
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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