STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB91999.1Dihydroorotate dehydrogenase (fumarate); InterProIPR017900:IPR001295:IPR012135:IPR017896:IPR 005720; COGs: COG0167 Dihydroorotate dehydrogenase; KEGG: cdl:CDR20291_1984 dihydroorotate dehydrogenase, catalytic subunit; SPTR: Dihydroorotate dehydrogenase, catalytic subunit; PFAM: dihydroorotate oxidase; TIGRFAM: dihydroorotate dehydrogenase family protein. (367 aa)    
Predicted Functional Partners:
SMB98873.1
4Fe-4S dicluster domain-containing protein; InterPro IPR017896:IPR017900; KEGG: dae:Dtox_1356 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Putative uncharacterized protein.
  
 0.999
SMB98875.1
NAD(P)H-flavin reductase; InterProIPR017927:IPR012165:IPR008333:IPR001433:IPR 019480:IPR001221; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; KEGG: rmr:Rmar_2588 oxidoreductase FAD/NAD(P)-binding domain protein; SPTR: Oxidoreductase FAD/NAD(P)-binding domain protein; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain.
 
 0.999
SMB98918.1
NADH-quinone oxidoreductase subunit F; InterProIPR001949:IPR009737:IPR011538:IPR019554:IPR 019575:IPR013027:IPR000759; COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; KEGG: dal:Dalk_2559 respiratory-chain NADH dehydrogenase domain 51 kDa subunit; SPTR: Respiratory-chain NADH dehydrogenase domain-containing protein; PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Sucraseferredoxin family protein; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; FAD-dependent pyridine nucleotide-disulphide oxidore [...]
 
 0.998
SMB90082.1
NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein; COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; KEGG: pth:PTH_2648 NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit; SPTR: NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit; InterProIPR017896:IPR017900:IPR001949:IPR011538:IPR 019554:IPR019575; PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; PRIAM: NADH dehydrogenase (quinone).
  
 0.996
SMB98921.1
NAD(P)-dependent iron-only hydrogenase iron-sulfur protein; SPTR: NADH dehydrogenase (Quinone); KEGG: mta:Moth_1718 NADH dehydrogenase (quinone).
  
 0.996
SMB89163.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterProIPR011895:IPR017896:IPR017900:IPR002880:IPR 019752:IPR019456:IPR011766; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: mta:Moth_0064 pyruvate:ferredoxin (flavodoxin) oxidoreductase; SPTR: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing p [...]
  
 0.994
pyrK
Dihydroorotate oxidase B, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
 0.994
SMB99550.1
Dihydropyrimidinase; InterPro IPR006680:IPR011778:IPR004722; COGs: COG0044 Dihydroorotase and related cyclic amidohydrolase; KEGG: mta:Moth_1997 dihydropyrimidinase; SPTR: Dihydropyrimidinase; PFAM: amidohydrolase; TIGRFAM: dihydropyrimidinase; dihydroorotase, multifunctional complex type.
 
 0.993
SMB95392.1
NADH dehydrogenase subunit M; InterPro IPR010227:IPR001750:IPR003918; COGs: COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M); KEGG: mta:Moth_0986 proton-translocating NADH-quinone oxidoreductase, chain M; SPTR: Proton-translocating NADH-quinone oxidoreductase, chain M; PFAM: NADH/Ubiquinone/plastoquinone (complex I); TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain M.
  
 0.991
nuoN
NADH dehydrogenase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family.
  
 0.991
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.