STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB92374.1Cysteine synthase; InterPro IPR000277; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; KEGG: mta:Moth_1989 cysteine synthase / cystathionine gamma-synthase; SPTR: Cysteine synthase / cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (377 aa)    
Predicted Functional Partners:
SMB92424.1
5-methyltetrahydrofolate--homocysteine methyltransferase; InterPro IPR000489; COGs: COG1410 Methionine synthase I cobalamin-binding domain; KEGG: tit:Thit_1600 homocysteine S-methyltransferase; SPTR: Putative uncharacterized protein; PFAM: dihydropteroate synthase DHPS; PRIAM: Methionine synthase.
  
 
 0.968
SMB98084.1
5,10-methylenetetrahydrofolate reductase (ferredoxin); InterPro IPR003171; COGs: COG0685 5 10-methylenetetrahydrofolate reductase; KEGG: mta:Moth_1191 methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 0.960
SMB98896.1
Cysteine synthase; InterPro IPR001216:IPR005856:IPR005859:IPR001926; COGs: COG0031 Cysteine synthase; KEGG: mta:Moth_1706 cysteine synthase; SPTR: Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; TIGRFAM: cysteine synthase A; cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.922
SMB93872.1
Cysteine synthase; InterPro IPR001926:IPR005856:IPR005859; COGs: COG0031 Cysteine synthase; KEGG: gur:Gura_3859 cysteine synthase A; SPTR: Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; TIGRFAM: cysteine synthase A; cysteine synthase.
 
 0.920
SMB89163.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterProIPR011895:IPR017896:IPR017900:IPR002880:IPR 019752:IPR019456:IPR011766; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: mta:Moth_0064 pyruvate:ferredoxin (flavodoxin) oxidoreductase; SPTR: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing p [...]
  
 
  0.897
SMB99559.1
Cysteine synthase; InterPro IPR001926; COGs: COG0031 Cysteine synthase; KEGG: mta:Moth_2000 pyridoxal-5'-phosphate-dependent enzyme, beta subunit; SPTR: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit.
  
 0.894
SMB99634.1
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase; InterPro IPR001763:IPR013027:IPR004099:IPR000815; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; KEGG: gme:Gmet_3484 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SMART: Rhodanese domain protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region.
  
 
 0.872
SMB94291.1
KEGG: mta:Moth_0833 hypothetical protein; SPTR: Putative uncharacterized protein.
  
 
 0.855
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
 0.838
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.829
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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