STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB93114.1COGs: COG1969 Ni Fe-hydrogenase I cytochrome b subunit; KEGG: Ni/Fe-hydrogenase, b-type cytochrome subunit; SPTR: Hup-type Ni,Fe-hydrogenase cytochrome b subunit. (204 aa)    
Predicted Functional Partners:
SMB93102.1
Hydrogenase small subunit; InterPro IPR001821:IPR017909:IPR006137:IPR006311; COGs: COG1740 Ni Fe-hydrogenase I small subunit; KEGG: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; PRIAM: Hydrogenase (acceptor); TIGRFAM: hydrogenase (NiFe) small subunit HydA; SPTR: Ni,Fe-hydrogenase small subunit.
 
 
 0.999
SMB93106.1
Hydrogenase large subunit; InterPro IPR001501:IPR018194; COGs: COG0374 Ni Fe-hydrogenase I large subunit; KEGG: dsy:DSY1598 Hup-type Ni,Fe-hydrogenase large subunit; SPTR: Hup-type Ni,Fe-hydrogenase large subunit; PFAM: nickel-dependent hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.999
SMB93118.1
COGs: COG0680 Ni Fe-hydrogenase maturation factor; KEGG: hydrogenase maturation protease; SPTR: Hydrogenase maturation protease; InterPro IPR000671; PFAM: peptidase M52 hydrogen uptake protein; TIGRFAM: hydrogenase maturation protease.
 
  
 0.966
SMB89163.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterProIPR011895:IPR017896:IPR017900:IPR002880:IPR 019752:IPR019456:IPR011766; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: mta:Moth_0064 pyruvate:ferredoxin (flavodoxin) oxidoreductase; SPTR: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing p [...]
   
  
 0.924
hypA-2
Hydrogenase nickel incorporation protein HypA/HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.866
SMB93127.1
Hydrogenase nickel incorporation protein HypB; InterPro IPR012202:IPR003495:IPR004392; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; KEGG: mta:Moth_2180 hydrogenase accessory protein HypB; SPTR: Hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; TIGRFAM: hydrogenase accessory protein HypB.
 
   
 0.859
SMB98886.1
InterPro IPR000671; COGs: COG0680 Ni Fe-hydrogenase maturation factor; KEGG: dau:Daud_1650 hydrogenase maturation protease; SPTR: Hydrogenase maturation protease; PFAM: peptidase M52 hydrogen uptake protein; TIGRFAM: hydrogenase maturation protease.
 
  
 0.850
SMB93092.1
F420-non-reducing hydrogenase large subunit; InterPro IPR001501:IPR018194; COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; KEGG: dau:Daud_1651 nickel-dependent hydrogenase, large subunit; SPTR: Nickel-dependent hydrogenase, large subunit; PFAM: nickel-dependent hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
  
 0.713
SMB98891.1
Hydrogenase expression/formation protein HypC; InterPro IPR019812:IPR001109; COGs: COG0298 Hydrogenase maturation factor; KEGG: adg:Adeg_2008 hydrogenase assembly chaperone HypC/HupF; SPTR: Hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); TIGRFAM: hydrogenase assembly chaperone hypC/hupF.
 
  
 0.644
SMB94916.1
Rubredoxin/NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family; InterPro IPR002563:IPR004039:IPR018527:IPR001052; COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; KEGG: mta:Moth_1288 flavin reductase-like, FMN-binding; SPTR: High molecular weight rubredoxin; PFAM: flavin reductase domain protein FMN-binding; Rubredoxin-type Fe(Cys)4 protein.
  
  
 0.594
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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