STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB95078.1Pyruvate dehydrogenase E1 component beta subunit; InterPro IPR005475:IPR005476:IPR013838; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; KEGG: bha:BH0777 acetoin dehydrogenase (TPP-dependent) beta chain; SPTR: Acetoin dehydrogenase (TPP-dependent) beta chain; PFAM: Transketolase central region; Transketolase domain-containing protein. (325 aa)    
Predicted Functional Partners:
SMB91648.1
InterPro IPR001017; COGs: COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type alpha subunit; KEGG: tte:TTE0688 thiamine pyrophosphate-dependent dehydrogenase, E1 component alpha subunit; SPTR: Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunit; PFAM: dehydrogenase E1 component; PRIAM: Pyruvate dehydrogenase (acetyl-transferring).
 0.999
pdhA
Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.999
SMB98403.1
InterPro IPR001017; COGs: COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type alpha subunit; KEGG: tex:Teth514_2033 pyruvate dehydrogenase (acetyl-transferring); SPTR: Pyruvate dehydrogenase E1 component subunit alpha; PFAM: dehydrogenase E1 component; PRIAM: Pyruvate dehydrogenase (acetyl-transferring).
 0.999
SMB95080.1
InterPro IPR000089:IPR004167:IPR001078; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; KEGG: tte:TTE0188 dihydrolipoamide acyltransferase; SPTR: 2-oxo acid dehydrogenases acyltransferase (Catalytic domain) protein; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein.
 0.998
SMB98395.1
InterPro IPR000089:IPR004167:IPR001078; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; KEGG: tex:Teth514_2030 dehydrogenase catalytic domain-containing protein; SPTR: Dihydrolipoyllysine-residue acetyltransferase component of acetoincleaving system; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; E3 binding domain protein; biotin/lipoyl attachment domain-containing protein; manually curated.
 0.992
SMB91634.1
2-oxoglutarate dehydrogenase E2 component; InterPro IPR003016:IPR000089:IPR004167:IPR001078; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; KEGG: tte:TTE0690 dihydrolipoamide acyltransferase; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; E3 binding domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: 2-oxo acid dehydrogenases acyltransferase (Catalytic domain) protein.
 0.990
SMB91631.1
Dihydrolipoamide dehydrogenase; InterProIPR012999:IPR013027:IPR004099:IPR000815:IPR 006258; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); KEGG: mta:Moth_1763 dihydrolipoamide dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; TIGRFAM: dihydrolipoamide dehydrogenase.
 0.960
SMB99013.1
Dihydrolipoamide dehydrogenase; InterProIPR012999:IPR006258:IPR013027:IPR004099:IPR 000815; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); KEGG: mta:Moth_1763 dihydrolipoamide dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; TIGRFAM: dihydrolipoamide dehydrogenase.
 0.959
SMB99389.1
2,4-dienoyl-CoA reductase; InterPro IPR001155:IPR001327:IPR013027:IPR000103; COGs: COG1902 NADH:flavin oxidoreductase Old Yellow Enzyme family; KEGG: tte:TTE2131 NADH:flavin oxidoreductase; SPTR: NADH:flavin oxidoreductases, Old Yellow Enzyme family; PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
 0.956
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.946
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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