STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB95302.1L-threonine aldolase; InterPro IPR001597; COGs: COG2008 Threonine aldolase; KEGG: drm:Dred_0105 threonine aldolase; SPTR: L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Threonine aldolase. (342 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.925
gcvPB
Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
    
 0.892
gcvPA
Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
    
 0.889
SMB98281.1
L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
   
 0.887
ychF
Hypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
      0.862
SMB98978.1
InterPro IPR013154:IPR013149; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; KEGG: bmq:BMQ_2819 zinc-binding dehydrogenase family protein; SPTR: Zinc-binding dehydrogenase family protein; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein.
 
   
  0.777
SMB99553.1
L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
   
 0.751
SMB88596.1
L-aspartate aminotransferase apoenzyme; InterPro IPR020578:IPR000192; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; KEGG: mta:Moth_0019 serine--glyoxylate transaminase; SPTR: Serine--glyoxylate transaminase; PFAM: aminotransferase class V.
    
 0.743
SMB95202.1
Aspartate aminotransferase; InterPro IPR000192; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; KEGG: mfs:MFS40622_1208 aminotransferase class V; SPTR: Aminotransferase class V; PFAM: aminotransferase class V.
    
 0.743
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
   
 0.648
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.