STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB96801.1AAA domain-containing protein; InterPro IPR003395; COGs: COG0419 ATPase involved in DNA repair; KEGG: tte:TTE2031 DNA repair ATPase; SPTR: ATPase involved in DNA repair; PFAM: SMC domain protein. (464 aa)    
Predicted Functional Partners:
sbcD
Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.991
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.984
SMB96899.1
RQC domain-containing protein; InterPro IPR000165:IPR018982; KEGG: adg:Adeg_0855 RQC domain protein; SPTR: RQC domain protein; PFAM: RQC domain.
  
 0.900
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.870
SMB96370.1
ATPase family associated with various cellular activities (AAA); InterPro IPR003960:IPR003593:IPR000641:IPR003959; COGs: COG1222 ATP-dependent 26S proteasome regulatory subunit; KEGG: mta:Moth_0309 AAA ATPase; SPTR: AAA ATPase; SMART: AAA ATPase; PFAM: AAA ATPase central domain protein.
  
 
 
 0.781
dinG
ATP-dependent DNA helicase DinG; 3'-5' exonuclease.
   
 0.749
SMB99518.1
DNA ligase-1; InterPro IPR012310:IPR012309:IPR014146; COGs: COG1793 ATP-dependent DNA ligase; KEGG: mta:Moth_1488 ATP dependent DNA ligase, central; SPTR: ATP dependent DNA ligase, central; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; TIGRFAM: DNA polymerase LigD, ligase domain protein.
   
 0.721
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.686
recA-2
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.686
SMB96800.1
KEGG: dka:DKAM_0025 protein of unknown function DUF814; SPTR: Putative uncharacterized protein.
       0.655
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.